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4281-32-7

4',7-dimethoxy-4-flavanol is a naturally occurring flavanol compound found in various plants, particularly in the leaves and bark of certain trees. It belongs to the flavonoid class of secondary metabolites, which are known for their antioxidant properties and potential health benefits. This specific compound is characterized by the presence of two methoxy groups at the 4' and 7 positions, and a hydroxyl group at the 4 position on the flavanol backbone. Research on 4',7-dimethoxy-4-flavanol has shown that it may possess anti-inflammatory, anti-cancer, and neuroprotective effects, although further studies are needed to fully understand its potential applications and mechanisms of action.

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  • 4281-32-7 Structure

  • Basic information

    1. Product Name: 4',7-dimethoxy-4-flavanol
    2. Synonyms: 4',7-dimethoxy-4-flavanol
    3. CAS NO:4281-32-7
    4. Molecular Formula:
    5. Molecular Weight: 286.328
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 4281-32-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4',7-dimethoxy-4-flavanol(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4',7-dimethoxy-4-flavanol(4281-32-7)
    11. EPA Substance Registry System: 4',7-dimethoxy-4-flavanol(4281-32-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 4281-32-7(Hazardous Substances Data)

4281-32-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4281-32-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,8 and 1 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4281-32:
(6*4)+(5*2)+(4*8)+(3*1)+(2*3)+(1*2)=77
77 % 10 = 7
So 4281-32-7 is a valid CAS Registry Number.

4281-32-7Downstream Products

4281-32-7Relevant articles and documents

Enantioselective Synthesis of Isoflavanones and Pterocarpans through a RuII-Catalyzed ATH-DKR of Isoflavones

Caleffi, Guilherme S.,Costa, Paulo R. R.,Costa-Júnior, Paulo C. T.,Gaspar, Francisco V.

, p. 5097 - 5108 (2021/10/20)

Noyori-Ikariya RuII complexes promoted the one-pot C=C/C=O bonds reduction of isoflavones using sodium formate as the hydrogen source through Asymmetric Transfer Hydrogenation-Dynamic Kinetic Resolution (ATH-DKR). Due to the neutral conditions employed, isoflavones with different substituents at the 2’-position of B-ring (H, OH, OMe and Br) were successfully reduced. Ten cis-3-phenylchroman-4-ols were selectively obtained (>20 : 1 dr) in good yields (up to 86 %) and excellent enantioselectivities (up to >99 : 1 er). The synthetic applications of these chiral compounds were also demonstrated. Enantioenriched isoflavanones were obtained under mild metal-free oxidation of the cis-3-phenylchroman-4-ols while pterocarpans were synthesized by two strategies: an acid-catalyzed cyclization and a novel approach based on a Pd-catalyzed C?O intramolecular cross-coupling reaction.

Enantioselective Synthesis of Isoflavanones by Catalytic Dynamic Kinetic Resolution

Qin, Tao,Metz, Peter

supporting information, p. 2981 - 2984 (2017/06/07)

A ruthenium-catalyzed asymmetric transfer hydrogenation of racemic isoflavanones with dynamic kinetic resolution yields virtually enantiopure isoflavanols as single diastereomers. Subsequent oxidation gives rise to isoflavanones in high enantiomeric purit

Synthesis, structure-activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors

Xiao, Zhu-Ping,Peng, Zhi-Yun,Dong, Jing-Jun,He, Juan,Ouyang, Hui,Feng, Yu-Ting,Lu, Chun-Lei,Lin, Wan-Qiang,Wang, Jin-Xiang,Xiang, Yin-Ping,Zhu, Hai-Liang

, p. 685 - 695 (2013/07/25)

In a continuing study for discovering urease inhibitors based on flavonoids, nineteen reductive derivatives of flavonoids were synthesized and evaluated against Helicobacter pylori urease. Analysis of structure-activity relationship disclosed that 4-deoxy analogues are more potent than other reductive products. Out of them, 4′,7,8-trihydroxyl-2-isoflavene (13) was found to be the most active with IC50 of 0.85 μM, being over 20-fold more potent than the commercial available urease inhibitor, acetohydroxamic acid (AHA). Kinetics study revealed that 13 is a competitive inhibitor of H. pylori urease with a Ki value of 0.641 μM, which is well matched with the results of molecular docking. Biological evaluation and mechanism study of 13 suggest that it is a good candidate for discovering novel anti-gastritis and anti-gastric ulcer agent.

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