42836-87-3

Usage

Uses

Used in Pharmaceutical Synthesis:
3,3'-Dimethoxy-5,5'-bi-1,2,4-triazine is used as a precursor in the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the development of new drugs with potential therapeutic applications.
Used in Agricultural Chemicals:
In the agricultural industry, 3,3'-Dimethoxy-5,5'-bi-1,2,4-triazine is used as a precursor for the synthesis of various agricultural chemicals. Its properties enable the creation of effective compounds for pest control and crop protection.
Used in Coordination Chemistry:
3,3'-Dimethoxy-5,5'-bi-1,2,4-triazine has been studied for its potential use as a ligand in coordination chemistry. Its ability to form stable complexes with metal ions makes it a promising candidate for applications in catalysis, materials science, and other areas of chemistry that require the use of metal-organic frameworks.

Upstream product

• 28735-22-0 3-methoxy-[1,2,4]triazine 
• 1255789-67-3 2-[(1,2,4-triazin-3-yl)thio]-N,N-dimethylethan-1-amine 
• 28735-21-9 3-methylthio-1,2,4-triazine 

Relevant academic research and scientific papers

A direct route to 6,6′-disubstituted-2,2′-bipyridines by double Diels-Alder/retro Diels-Alder reaction of 5,5′-bi-1,2,4-triazines

Inverse electron demand Diels-Alder reaction of functionalized 5,5′-bi-1,2,4-triazines with bicyclo[2.2.1]hepta-2,5-diene in boiling p-cymene leads to a range of 6,6′-disubstituted-2,2′-bipyridines in good yield.

Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines

Novel 3,3′-disubstituted-5,5′-bi(1,2,4-triazine) compounds with potent in vitro activity against Plasmodium falciparum parasites were recently discovered. To improve the pharmacokinetic properties of the triazine derivatives, a new structure-activity relationship (SAR) investigation was initiated with a focus on enhancing the metabolic stability of lead compounds. These efforts led to the identification of second-generation highly potent antimalarial bis-triazines, exemplified by triazine 23, which exhibited significantly improved in vitro metabolic stability (8 and 42 μL/min/mg protein in human and mouse liver microsomes). The disubstituted triazine dimer 23 was also observed to suppress parasitemia in the Peters 4-day test with a mean ED50 value of 1.85 mg/kg/day and exhibited a fast-killing profile, revealing a new class of orally available antimalarial compounds of considerable interest.

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

A series of 3,3′-disubstituted 5,5′-bi(1,2,4-triazine) derivatives was synthesized and screened against the erythrocytic stage of Plasmodium falciparum 3D7 line. The most potent dimer, 6k, with an IC50 (50% inhibitory concentration) of 0.008 μM, had high in vitro potency against P. falciparum lines resistant to chloroquine (W2, IC50 = 0.0047 ± 0.0011 μM) and artemisinin (MRA1240, IC50 = 0.0086 ± 0.0010 μM). Excellent ex vivo potency of 6k was shown against clinical field isolates of both P. falciparum (IC50 = 0.022-0.034 μM) and Plasmodium vivax (IC50 = 0.0093-0.031 μM) from the blood of outpatients with uncomplicated malaria. Despite 6k being cleared relatively rapidly in mice, it suppressed parasitemia in the Peters 4-day test, with a mean ED50 value (50% effective dose) of 1.47 mg kg-1 day-1 following oral administration. The disubstituted triazine dimer 6k represents a new class of orally available antimalarial compounds of considerable interest for further development.

3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity

We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.

Herbicidal 5,5'-bis-1,2,4-triazinyls

Herbicidally active 5,5'-bis-1,2,4-triazinyl compounds, compositions and methods of using same to control undesired vegetation.