28735-22-0

Basic information

• Product Name: METHYL 1,2,4-TRIAZIN-3-YL ETHER
• Synonyms: METHYL 1,2,4-TRIAZIN-3-YL ETHER;3-METHOXY-[1,2,4]TRIAZINE
• CAS NO: 28735-22-0
• Molecular Formula: C4H5N3O
• Molecular Weight: 111.1
• Mol File: 28735-22-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 48 °C
• Boiling Point: 209.6°Cat760mmHg
• Flash Point: 75.7°C
• Appearance: /
• Density: 1.193
• Vapor Pressure: 0.291mmHg at 25°C
• Refractive Index: 1.496
• PKA: 2.18±0.63(Predicted)
• CAS DataBase Reference: METHYL 1,2,4-TRIAZIN-3-YL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 1,2,4-TRIAZIN-3-YL ETHER(28735-22-0)
• EPA Substance Registry System: METHYL 1,2,4-TRIAZIN-3-YL ETHER(28735-22-0)

Safety Data

• Hazardous Substances Data: 28735-22-0(Hazardous Substances Data)

Usage

General Description

Methyl 1,2,4-triazin-3-yl ether is a chemical compound that is commonly used as a reagent in organic synthesis, pharmaceutical manufacturing, and agricultural products. It is a versatile compound with a range of applications, including as a building block for the synthesis of biologically active molecules and as an intermediate in the production of herbicides and fungicides. Methyl 1,2,4-triazin-3-yl ether is also known for its ability to form stable complexes with metal ions, making it useful in catalytic and coordination chemistry. Additionally, it is a valuable tool in the research and development of new materials and pharmaceuticals due to its unique chemical properties and potential for diverse functionalization.

InChI:InChI=1/C4H5N3O/c1-8-4-5-2-3-6-7-4/h2-3H,1H3

Upstream product

• 124-41-4 sodium methylate 
• 28735-21-9 3-methylthio-1,2,4-triazine 
• 67-56-1 methanol 
• 105783-77-5 3-methanesulphonyl-[1,2,4]triazine 

Downstream Products

• 42836-87-3 3,3'-bis(methoxy)-5,5'-bi-1,2,4-triazine 
• 42836-88-4 3,3'-bis(methylsulfanyl)-5,5'-bi-1,2,4-triazine 
• 68943-85-1 3-methoxy-5-(3-methylthio-1,2,4-triazin-5-yl-)-1,2,4-triazine 
• 1255789-71-9 C₁₄H₂₂N₈S₂ 

Relevant articles and documents

Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines

Novel 3,3′-disubstituted-5,5′-bi(1,2,4-triazine) compounds with potent in vitro activity against Plasmodium falciparum parasites were recently discovered. To improve the pharmacokinetic properties of the triazine derivatives, a new structure-activity relationship (SAR) investigation was initiated with a focus on enhancing the metabolic stability of lead compounds. These efforts led to the identification of second-generation highly potent antimalarial bis-triazines, exemplified by triazine 23, which exhibited significantly improved in vitro metabolic stability (8 and 42 μL/min/mg protein in human and mouse liver microsomes). The disubstituted triazine dimer 23 was also observed to suppress parasitemia in the Peters 4-day test with a mean ED50 value of 1.85 mg/kg/day and exhibited a fast-killing profile, revealing a new class of orally available antimalarial compounds of considerable interest.

3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity

We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.