42843-19-6Relevant academic research and scientific papers
Asymmetric dihydroxylation of disubstituted allenes
Fleming, Steven A.,Liu, Renmao,Redd, J. Ty
, p. 8095 - 8098 (2007/10/03)
Asymmetric dihydroxylation of 1,1-disubstituted and 1,3-disubstituted allenes can be used to synthesize chiral α-hydroxy ketones. We have also obtained α,α′-dihydroxy ketones with high enantioselectivity from 1,3-disubstituted allenes. Low conversion of the dihydroxylation of chiral allenes can be used as a kinetic resolution of sterically hindered allenes.
Enantioselective synthesis of α-branched α-hydroxy ketones via chiral N-sulfonyl-2-alkyl-2-cyano-1,3-oxazolidines
Harder, Timm,Loehl, Thorsten,Bolte, Michael,Wagner, Kerstin,Hoppe, Dieter
, p. 7365 - 7368 (2007/10/02)
The stereochemically homogeneous title compounds 6, prepared with two steps from orthoesters and N-tosyl-phenylglycinol 4, afford with two sequential Grignard additions predominantly the tertiary alcohols 8. Electrochemical detosylation, followed by aqueo
Stereocontrolled Addition Reaction of Organometallics to Chiral α-Keto Amides
Fujisawa, Tamotsu,Ukaji, Yutaka,Funabora, Makoto,Yamashita, Mikio,Sato, Toshio
, p. 1894 - 1897 (2007/10/02)
Complementary stereoselection in the addition reaction of several organometallics to chiral benzoylformamide, prepared from benzoylformic acid and (S)-2-(methoxymethyl)pyrrolidine, could be achieved using magnesium- and titanium-based reagents to give different diastereomers of atrolactamide.On the other hand, the reaction of phenyl metallics to the corresponding pyruvamide afforded (S)-atrolactamide.
