(3S)-3-Hydroxy-3-phenylbutan-2-one

Base Information

Chemical Name:(3S)-3-Hydroxy-3-phenylbutan-2-one
CAS No.:42843-19-6
Molecular Formula:C₁₀H₁₂O₂
Molecular Weight:164.204
Hs Code.:
DSSTox Substance ID:DTXSID30505816
Nikkaji Number:J1.365.383F
Wikidata:Q82361150
Mol file:42843-19-6.mol

Synonyms:(3S)-3-Hydroxy-3-phenylbutan-2-one;42843-19-6;SCHEMBL890229;DTXSID30505816

Suppliers and Price of (3S)-3-Hydroxy-3-phenylbutan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (3S)-3-Hydroxy-3-phenylbutan-2-one

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:164.083729621
Heavy Atom Count:12
Complexity:171

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C(C)(C1=CC=CC=C1)O
Isomeric SMILES:CC(=O)[C@](C)(C1=CC=CC=C1)O

Technology Process of (3S)-3-Hydroxy-3-phenylbutan-2-one

There total 8 articles about (3S)-3-Hydroxy-3-phenylbutan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 917-54-4
methyllithium

: 78805-22-8
(S)--2-(methoxymethyl)pyrrolidine

: 42843-19-6
(S)-3-hydroxy-3-phenyl-2-butanone

: 78805-32-0
(S)-3-methyl-2-phenyl-2,3-butanediol

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; for 12h;
DOI:10.1246/bcsj.63.1894

Reference yield:

: 1-[(2S,4R)-2-Methyl-4-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-1-phenyl-ethanol

: 42843-19-6
(S)-3-hydroxy-3-phenyl-2-butanone

: 42843-18-5
(3R)-3-hydroxy-3-phenylbutan-2-one

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; In acetonitrile; at 0 ℃; for 0.5h; Yield given. Yields of byproduct given; electrolysis;
DOI:10.1016/0040-4039(94)85315-0

Reference yield:

: 98-86-2
acetophenone

: 42843-19-6
(S)-3-hydroxy-3-phenyl-2-butanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1) Li-TMP / tetrahydrofuran; pentane; diethyl ether / 5 h / -100 °C

2: diethyl ether; tetrahydrofuran / 24 h / 20 °C

With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; diethyl ether; pentane;