42869-47-6

Usage

Uses

Used in Pharmaceutical Industry:
6-BROMO-2-METHYL-4H-IMIDAZO[4,5-B]PYRIDINE is used as a building block for the synthesis of various bioactive molecules, such as kinase inhibitors and antiviral drugs. Its unique structure and properties make it a valuable component in the development of new pharmaceuticals.
Used in Medicinal Chemistry and Drug Discovery:
6-BROMO-2-METHYL-4H-IMIDAZO[4,5-B]PYRIDINE is utilized in the field of medicinal chemistry and drug discovery due to its potential to contribute to the creation of novel therapeutic agents. Its role as a GABAA receptor modulator further enhances its pharmacological interest, making it a promising candidate for research and development in these areas.

InChI:InChI=1/C7H6BrN3/c1-4-10-6-2-5(8)3-9-7(6)11-4/h2-3H,1H3,(H,9,10,11)

Upstream product

• 38875-53-5 5-bromo-pyridine-2,3-diamine 
• 64-19-7 acetic acid 
• 103-79-7 1-phenyl-acetone 
• 67-64-1 acetone 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 563-80-4 3-methyl-butan-2-one 
• 65148-08-5 5-bromo-2,3-diacetamidopyridine 

Downstream Products

• 1312715-95-9 (E)-5-bromo-2-(4-cyanostyryl)-1H-imidazo[4,5-b]pyridine 
• 92260-32-7 6-bromo-2,3-dimethyl-3H-imidazo[4,5-b]pyridine 
• 1257320-82-3 6-bromo-2-methyl-1-(triphenylmethyl)-1H-imidazo[4,5-b]pyridine 

Relevant academic research and scientific papers

CONDENSED HETEROCYCLIC COMPOUND

Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein.].

Heterocyclisation via Selective Elimination: Reaction of 2,3-Diaminopyridine with Acyclic Ketones under Thermal Conditions

Reactions of 2,3-diaminopyridine and its 5-bromo analogue with three symmetrical and nine unsymmetrical acyclic ketones under thermal conditions have been studied.The reactions have yielded 2-substituted-1H-imidazopyridines by the elimination of one of the C2-substituents from the probable, though unisolated, intermediates 2,2-disubstituted-2,3-dihydro-1H-imidazopyridine derivatives.Elimination of one of the groups in the case of symmetrical ketones and preferentially of benzyl group in the case of benzyl methyl ketone has been observed.All the three alkyl phenyl ketones studied afford 2-phenylimidazopyridine by the selective loss of the alkyl group.Elimination of branched alkyl group has been noticed in the reactions involving methyl t-butyl and methyl i-propyl ketones, while the preferential elimination of methyl group is observed in the case of methyl n-alkyl ketones.Suitable explanations have been offered for the observed selective eliminations.