4287-30-3

Basic information

• Product Name: 2-[(3,5-DIMETHYLPHENOXY)METHYL]OXIRANE
• Synonyms: 2-[(3,5-DIMETHYLPHENOXY)METHYL]OXIRANE;Oxirane, [(3,5-dimethylphenoxy)methyl]-
• CAS NO: 4287-30-3
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• Mol File: 4287-30-3.mol

Chemical Properties

• Boiling Point: 283.8°C at 760 mmHg
• Flash Point: 115.3°C
• Appearance: /
• Density: 1.071g/cm³
• Vapor Pressure: 0.00531mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: 2-[(3,5-DIMETHYLPHENOXY)METHYL]OXIRANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(3,5-DIMETHYLPHENOXY)METHYL]OXIRANE(4287-30-3)
• EPA Substance Registry System: 2-[(3,5-DIMETHYLPHENOXY)METHYL]OXIRANE(4287-30-3)

Safety Data

• Hazardous Substances Data: 4287-30-3(Hazardous Substances Data)

Usage

Uses

3,5-Dimethylphenoxymethyloxirane is a reactant used in the preparation of thiiranes.

InChI:InChI=1/C11H14O2/c1-8-3-9(2)5-10(4-8)12-6-11-7-13-11/h3-5,11H,6-7H2,1-2H3

Upstream product

• 108-68-9 3,5-Dimethylphenol 
• 106-89-8 epichlorohydrin 
• 1123-09-7 3,5-dimethyl-2-cyclohexen-1-one 
• 556-52-5 oxiranyl-methanol 

Downstream Products

• 6078-88-2 3-<3,5-Dimethyl-phenoxy>-1-diallylamino-propanol-(2) 
• 89514-57-8 1-(3,5-Dimethylphenoxy)-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinyloxy)ethylamino]-2-propanol 
• 1422444-20-9 4-((3,5-dimethylphenoxy)methyl)-1,3-dioxolan-2-one 
• 59961-86-3 3-chloro-1-(3,5-dimethylphenoxy)-2-propanol 
• 502605-82-5 1-Benzylamino-3-(3,5-dimethyl-phenoxy)-propan-2-ol 

Relevant articles and documents

Carbon isotope labeling of carbamates by late-stage [11C], [13C] and [14C]carbon dioxide incorporation

A general procedure for the late-stage [11C], [13C] and [14C]carbon isotope labeling of cyclic carbamates is reported. This protocol allows the incorporation of carbon dioxide, the primary source of carbon-14 and carbon-11 radioisotopes, in a direct, cost-effective and sustainable manner. A disconnection/reconnection strategy, involving ring opening/isotopic closure, was also implemented.

Metal-Free I2-Catalyzed Highly Selective Dehydrogenative Coupling of Alcohols and Cyclohexenones

The I2 catalyzed highly selective oxidative condensation of cyclohexenones and alcohols for the synthesis of aryl alkyl ethers has been described. DMSO is employed as the mild terminal oxidant. This novel methodology offers a metal-free reaction condition, operational simplicity and broad substrate scope to afford valuable products from inexpensive reagents. Various meta-substituted aromatic ethers which are hardly synthesized from the reported methods requiring meta-substituted phenols, are efficiently prepared by the present protocol.

An Au-Catalyzed Cyclialkylation of Electron-Rich Arenes with Epoxides to Prepare 3-Chromanols

A gold-catalyzed cyclialkylation of electron-rich arenes with tethered epoxides afforded 3-chromanols stereospecifically. Copyright

Synthesis of some 3-aryloxymethyl-3,4-dihydroisocoumarins

Various 3-aryloxymethyl-3,4-dihydroisocoumarins 5a-1 have been synthesized by alkylation of the ortho-lithio derivatives of N-methyl benzamides 2a-c with 2-aryloxymethyl oxiranes 3a-d followed by the alkaline hydrolysis of the resultant intermediates 4a-1.

Efficient asymmetric hydrogenation of α-amino ketone derivatives. A highly enantioselective synthesis of phenylephrine, levamisole, carnitine and propranolol

The complexes of pyrrolidine bisphosphine ligands (CPMs) with rhodium (I) were found to be efficient catalysts for asymmetric hydrogenation of α-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient asymmetric syntheses of the optically active β-amino alcohols, phenylephrine, levamisole, carnitine and propranolol.