428863-07-4Relevant academic research and scientific papers
Mycobacterium tuberculosis β-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: Total synthesis and structure activity relationships
Richardson, Mark B.,Torigoe, Shota,Yamasaki, Sho,Williams, Spencer J.
supporting information, p. 15027 - 15030 (2015/10/12)
Mycobacterium tuberculosis H37Ra produces a range of immunogenic β-gentiobiosyl diacylglycerides. We report the total synthesis of several candidate structures and show that these compounds signal weakly through mouse, but not human, Mincle. Structure-activity relationships reveal a striking dependence upon acyl chain length for gentiobiosyl diacylglyceride signalling through Mincle. Significantly, a truncated β-glucosyl diglyceride was shown to provide potent signalling through both human and mouse Mincle and could activate murine bone marrow derived dendritic cells.
Synthesis and mesogenic properties of glycosyl diacylglycerols.
von Minden,Morr,Milkereit,Heinz,Vill
, p. 55 - 80 (2007/10/03)
We synthesised glycosyl diacylglycerols bearing unsaturated or chiral methyl branched fatty acid chains. The thermotropism was measured with polarising microscopy and additionally the lyotropism with the contact preparation method. The synthesised compoun
