428871-03-8

Upstream product

• 99197-84-9 ethyl 3-(3,4,5,6-tetrahydro-2H-pyran-4-yl) propionate 
• 133243-97-7 3-(tetrahydro-4H-pyran-4-ylidene)propan-1-ol 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 428871-01-6 2-(tetrahydro-2H-pyran-4-yl)ethyl methanesulfonate 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 952685-59-5 3-(tetrahydro-2H-pyran-4-yl)propanal 
• 952685-60-8 (S)-dibenzyl 1-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)hydrazine-1,2-dicarboxylate 

Relevant academic research and scientific papers

DIAMINOPROPANOL RENIN INHIBITORS

Described are diaminopropanols of which are orally active and bind to renin to inhibit its activity. They are useful in the treatment or amelioration of diseases associated with elevated levels of renin activity or in the treatment of aspartic protease me

BENZIMIDAZOLE DERIVATIVES

This invention relates to the compounds represented by a general formula [I]: ???[in which A1 and A2 represent optionally fluorine-substituted methine or the like; B represents halogen, cyano, lower alkyl or the like; D represents optionally substituted heterocyclic group or the like; and G represents C3-C20 aliphatic group such as alicyclic group]. These compounds inhibit nociceptin activities due to their high affinity to nociceptin receptor, and are useful as analgesic, antiobestic, corebral function improver, drugs for treatment of alzheimer's disease and dementia, remedies for schizophrenia and neurodegenerative diseases, antidepressant, remedies for diabetes insipidus, polyuria, hypotension and so on.