42899-59-2

Usage

Uses

Used in Coordination Chemistry:
1,3-Bis(4-pyridyl)-1,3-propanedione is used as a chelating ligand for forming coordination complexes with metal ions, which is crucial in various chemical reactions and processes.
Used in Catalysis:
In the catalysis industry, 1,3-Bis(4-pyridyl)-1,3-propanedione is used as a catalyst or catalyst precursor to enhance the rate of chemical reactions, particularly those involving metal ions.
Used in Luminescent Materials:
1,3-Bis(4-pyridyl)-1,3-propanedione is utilized in the development of luminescent materials due to its ability to form complexes that exhibit light-emitting properties, which are important in areas such as sensors and optoelectronics.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1,3-Bis(4-pyridyl)-1,3-propanedione is used as a building block for the synthesis of pharmaceutical compounds, taking advantage of its metal-chelating properties to create potential therapeutic agents.
Used in Antioxidant and Anti-inflammatory Research:
1,3-Bis(4-pyridyl)-1,3-propanedione is studied for its potential antioxidant and anti-inflammatory properties, indicating its use in the development of treatments for conditions associated with oxidative stress and inflammation.

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 1570-45-2 isonicotinic acid ethylester 
• 100-48-1 pyridine-4-carbonitrile 
• 39178-35-3 isonicotinoyl chloride hydrochloride 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 

Downstream Products

• 79476-40-7 1-Phenyl-3,5-di(4-pyridyl)pyrazole 

Relevant academic research and scientific papers

A Dy4 Cubane: A New Member in the Single-Molecule Toroics Family

Molecular materials that possess a toroidal moment associated to a non-magnetic ground state are known as single-molecule toroics (SMTs) and are usually planar molecules. Herein, we report a Dy4 cubane, namely [Dy4(Bppd)4(μ3-OH)4(Pa)4(H2O)4]?0.333 H2O (where BppdH=1,3-Bis(pyridin-4-yl)propane-1,3-dione and PaH=2-Picolinic acid) for which magnetometry measurements and state-of-art ab initio calculations highlight SMT behavior in a tridimensional structure (3D-SMT). The in-depth theoretical analysis on the resulting low-lying energy states, along with their variation in function of the magnetic exchange pathways, allows further light to be shed on the description of single-molecule toroics and identify the coupling scheme that better reproduces the observed data.

A three-dimensional cubic halogen-bonded network

The rational, deliberate design of supramolecular architectures is of great importance for the discovery of complex materials. A three-dimensional cubic halogen-bonded network has been prepared by combination of an octahedral metal-containing halogen bond acceptor and a linear ditopic donor. This material displays α-Po pcu topology and is seven-fold interpenetrated. This is the first neutral, metal-containing three-dimensional halogen-bonded network to be reported.

Synthesis, anticonvulsant activity and QSAR studies of some new pyrazolyl pyridines

Twenty-one new 3,5-bipyridinyl-1H-pyrazole derivatives (pyrazolyl pyridines) have been synthesized and evaluated for their anticonvulsant activity in animal models of epilepsy. The pyrazolyl pyridines, 7–27, were obtained through a general one-pot synthes

Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases

Abstract The tankyrases are members of the PARP superfamily; they poly(ADP-ribosyl)ate their target proteins using NAD+ as a source of electrophilic ADP-ribosyl units. The three principal protein substrates of the tankyrases (TRF1, NuMA and axin) are involved in replication of cancer cells; thus inhibitors of the tankyrases may have anticancer activity. Using structure-based drug design and by analogy with known 3-arylisoquinolin-1-one and 2-arylquinazolin-4-one inhibitors, series of arylnaphthyridinones, arylpyridinopyrimidinones and their tetrahydro-derivatives were synthesised and evaluated in vitro. 7-Aryl-1,6-naphthyridin-5-ones, 3-aryl-2,6-naphthyridin-1-ones and 3-aryl-2,7-naphthyridin-1-ones were prepared by acid-catalysed cyclisation of the corresponding arylethynylpyridinenitriles or reaction of bromopyridinecarboxylic acids with β-diketones, followed by treatment with NH3. The 7-aryl-1,6-naphthyridin-5-ones were methylated at 1-N and reduced to 7-aryl-1-methyl-1,2,3,4-tetrahydro-1,6-naphthyridin-5-ones. Cu-catalysed reaction of benzamidines with bromopyridinecarboxylic acids furnished 2-arylpyrido[2,3-d]pyrimidin-4-ones. Condensation of benzamidines with methyl 1-benzyl-4-oxopiperidine-3-carboxylate and deprotection gave 2-aryl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ones, aza analogues of the known inhibitor XAV939. Introduction of the ring-N in the arylnaphthyridinones and the arylpyridopyrimidinones caused >1000-fold loss in activity, compared with their carbocyclic isoquinolinone and quinazolinone analogues. However, the 7-aryl-1-methyl-1,2,3,4-tetrahydro-1,6-naphthyridin-5-ones showed excellent inhibition of the tankyrases, with some examples having IC50 = 2 nM. One compound (7-(4-bromophenyl)-1-methyl-1,2,3,4-tetrahydro-1,6-naphthyridin-5-one) showed 70-fold selectivity for inhibition of tankyrase-2 versus tankyrase-1. The mode of binding was explored through crystal structures of inhibitors in complex with tankyrase-2.

Formation of HoIII trinuclear clusters and GdIII monodimensional polymers induced by ortho and para regioisomers of pyridyl-functionalised a-diketones: Synthesis, structure, and magnetic properties

Reaction of GdCl3(H2O)6 and 1,3-bis(pyridin-4-yl)propane-1,3-dione in methanol with an excess of triethylamine produced a monodimensional polymeric chain [Gd(p-dppd) 3-(H2O)]∞, whereas treatment of HoCl 3(H2O)6 with 1,3-bis(pyridin-2-yl)propane-1,3- dione yielded a trinuclear cluster [Ho3(o-dppd) 3(μ3-OH)2(H2O)4Cl 2]Cl2. The compounds were characterised by elemental analysis, IR spectroscopy and magnetism, and their structures were investigated by X-ray crystallography. The 8.20-μB magnetic-moment value of the polymeric [Gd(p-dppd)3(H2O)]∞, between 300 and 20 K, and the magnetisation isotherms (2-20 K; fields 0-5 T), are in agreement with essentially uncoupled single-ion Gd3+ f7 centres, a small decrease in μeff below 20 K being indicative of zero-field splitting. A temperature-dependent dc-susceptibility and magnetisation investigation of the trinuclear (tri-angular) [Ho 3(o-dppd)3(μ3-OH)2(H 2O)4Cl2]Cl2 revealed that spin-orbit and ligand-field effects on the Ho3+ centres, leading to thermal depopulation of Zeeman levels and consequent decreases in μeff values with decreasing temperature, are occurring rather than weak intra-cluster antiferromagnetic coupling. Frequency- and temperature-dependent acsusceptibility studies on this homometallic Ho3+ cluster did not show clear evidence for slow magnetisation reversal, characteristic of single-molecule magnetism (SMM), and this contrasts with such behaviour recently reported, elsewhere, for a Dy3+ triangle having the same core structure but with different chelating {O,O} ligands. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.