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Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Methoxyphenoxy)-2-propanol is used as an expectorant for the relief of chest congestion and coughs caused by common cold, bronchitis, and other respiratory infections. It functions by enhancing the volume and decreasing the viscosity of secretions in the respiratory tract, making it easier for individuals to cough up mucus.
Available in various forms such as tablets, syrups, and liquids, guaifenesin is a widely accessible medication for respiratory relief. However, it is crucial to consult with a healthcare professional before use, particularly for those with specific medical conditions or who are taking other medications, to prevent potential side effects or interactions.

Upstream product

• 1122-95-8 sodium 4-methoxyphenolate 
• 127-00-4 1-Chloro-2-propanol 
• 2211-94-1 2,3-epoxypropyl p-methoxyphenyl ether 
• 150-76-5 4-methoxy-phenol 
• 75-56-9 methyloxirane 

Downstream Products

• 947665-60-3 1-[2-(benzyloxy)propoxy]-4-methoxybenzene 
• 70145-86-7 1-(4-Methoxy-phenoxy)-2-hydrazino-propan 
• 91799-55-2 2-Brom-1-(4-methoxy-phenoxy)-propan 

Relevant academic research and scientific papers

Ruthenium-Catalyzed Selective Hydrogenation of Epoxides to Secondary Alcohols

A ruthenium(II)-catalyzed highly selective Markovnikov hydrogenation of terminal epoxides to secondary alcohols is reported. Diverse substitutions on the aryl ring of styrene oxides are tolerated. Benzylic, glycidyl, and aliphatic epoxides as well as diepoxides also underwent facile hydrogenation to provide secondary alcohols with exclusive selectivity. Metal-ligand cooperation-mediated ruthenium trans-dihydride formation and its reaction involving oxygen and the less substituted terminal carbon of the epoxide is envisaged for the origin of the observed selectivity.

Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)

As a continuation of our project aimed at the search for new chemotherapeutic agents against Chagas' disease, several drugs structurally related to the insect growth regulator Fenoxycarb and the naturally occurring juvenfie hormone of insects were designed, synthesized, and evaluated as antiproliferative agents against the parasite responsible of this disease. Isoprenoid derivatives (compounds 33, 34, 36, and 37) were potent growth inhibitors of Trypanosoma cruzi epimastigotes. In addition, taking into account the high activity observed for compound 30 and the inhibitory action of related compounds, the allyl ether moiety bonded at the polar extreme of these inhibitors proved to be a promising group for the design of new drugs.