78272-44-3

Basic information

• Product Name: Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-methyl ester; compound with pyridine
• Synonyms: Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-methyl ester; compound with pyridine
• CAS NO: 78272-44-3
• Molecular Weight: 703.753
• Mol File: 78272-44-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-methyl ester; compound with pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-methyl ester; compound with pyridine(78272-44-3)
• EPA Substance Registry System: Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-methyl ester; compound with pyridine(78272-44-3)

Safety Data

• Hazardous Substances Data: 78272-44-3(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 3711-50-0 phosphorochloridothioic acid,O,S-dimethyl ester 
• 42926-80-7 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine 

Relevant articles and documents

NOUVELLE SYNTHESE SIMPLE DE NUCLEOSIDE PHOSPHOROTHIOLATE

The O,S-dimethylphosphorochloridate 10 reacts with 5'-O-monomethoxytritylthymidine 11 in pyridine giving nucleoside-3'-thiolophosphodiester 13 in high yields ; in acetonitrile and in the presence of 1-methylimidazole, this reaction leads to the nucleoside-3'-phosphotriester 14 without formation of diester 13.From the latter, the Tp and TpT have been prepared.