42927-70-8

Upstream product

• 70147-50-1 (3S)-O²,O³-isopropylidene-β-L-apiofuranose 
• 1176306-06-1 1-O-3,4-(dihydroxyphenyl)ethyl-β-D-apiofuranosyl-(1->2)-4-O-caffeoyl-β-D-glucopyranoside 
• 1207273-49-1 2-O-[(2S,3R,4S)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)furan-2-yl]-1-O-[(3β)-3-(β-D-glucopyranosyloxy)-28-oxoolean-12-en-28-yl]-β-D-glucopyranose 
• 109445-40-1 O³-benzyl-2-hydroxymethyl-D-arabino-hexitol 
• 89364-39-6 (3Ξ)-D-3,4-anhydro-apiose 
• 14048-35-2 (-)-(3aR,6S,6aR)-6-hydroxymethyl-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol 
• 78694-77-6 7-((2S,3R,4R)-3,4-Dihydroxy-4-hydroxymethyl-tetrahydro-furan-2-yloxy)-3-[4-((2R,3S,4S)-3,4-dihydroxy-4-hydroxymethyl-tetrahydro-furan-2-yloxy)-phenyl]-5-hydroxy-chromen-4-one 
• 78693-95-5 7,4'-di-O-<4-O-β-D-glucopyranosyl-β-D-apiofuranoside> genisteol 
• 70147-50-1 3-C-hydroxymethyl-2,3-O-isopropylidene-β-D-erythrofuranoside 
• 111252-14-3 (23S)-3β-[(O-β-D-apiofuranosyl-(1->2)-O-β-D-glucopyranosyl-(1->2)-O-α-L-arabinopyranosyl-(1->6)-β-D-glucopyranosyl)oxy]-17α,23-epoxy-29-hydroxy-27-norlanost-8-ene-15,24-dione 
• 34724-16-8 1,2;3,3'-di-O-isopropylidene-3-C-(hydroxymethyl)-α-D-erythrofuranose 
• 1176306-07-2 1-O-3,4-(dihydroxyphenyl)ethyl-β-D-apiofuranosyl-(1->2)-β-D-xylopyranosyl-(1->3)-4-O-caffeoyl-β-D-glucopyranoside 
• 1217268-01-3 scutellarein-7-O-β-D-apiofuranoside 
• 1217268-02-4 apigenin-7-O-β-D-apiofuranosyl-(1->2)-β-D-apiofuranoside 

Downstream Products

• 109941-37-9 3-hydroxymethyl-[2]tetrosulose-bis-(2,5-dichloro-phenylhydrazone) 
• 64481-63-6 methyl 3-C-(hydroxymethyl)-α-L-threofuranoside 
• 64481-62-5 methyl 3-C-(hydroxymethyl)-β-L-threofuranoside 
• 64481-65-8 methyl 3-C-(hydroxymethyl)-β-D-erythrofuranoside 
• 64481-64-7 methyl 3-C-(hydroxymethyl)-α-D-erythrofuranoside 
• 10592-17-3 (3S)-2-hydroxymethylbutane-1,2,3,4-tetrol 
• 34724-16-8 1,2;3,3'-di-O-isopropylidene-3-C-(hydroxymethyl)-α-D-erythrofuranose 

Relevant academic research and scientific papers

Phenolic glycosides from Rhodohypoxis baurii

Three new phenolic glycosides (1-3), together with a known glycoside (4), were isolated from the bulbs of Rhodohypoxis baurii (Hypoxidaceae). The structures of the new glycosides (1-3) were determined on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR data, and of hydrolytic cleavage followed by chromatographic or spectroscopic analyses.

New benzoic acid glycosides from Sophora flavescens

Two new benzoic acid derivatives, sophophenoside A (1) and sophophenoside B (2), were isolated from Sophora flavescens. Their structures were elucidated by detailed spectroscopic analysis and chemical methods. Compounds 1 and 2 were assayed for their hepatoprotective activity on the cytotoxic effect of D-galactosamine on HL-7702 cells, and compound 1 exhibited a moderate hepatoprotective activity at a concentration of 10 μM.

The caffeoyl phenylethanoid glycosides from Lindernia ruellioides and their anti-HBV effects

Five caffeoyl phenylethanoid glycosides, including two new ones linderruelliosides A (1) and B (2), were isolated from the leaves and stems of Lindernia ruellioides. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR and MS spectra. In addition, all these compounds were tested for their anti-HBV activity. Compounds 1, 3, and 4 showed anti-HBV activities, with IC50 values of 54.87, 30.74, and 69.02?μM for HBsAg and 26.70, 5.17, and 7.08?μM for HBeAg, respectively.

Eight ent-kaurane diterpenoid glycosides named diosmariosides a-h from the leaves of diospyros maritima and their cytotoxic activity

From the leaves of Diospyros maritima, collected from Okinawa Island, eight new glycosides based on ent-kaurane-type diterpenoids, entitled diosmariosides A-H, were isolated. The absolute structure of diosmarioside E (5) was determined by X-ray crystallographic analysis. The structure of diosmarioside H was elucidated to be a dimeric compound between diosmarioside A and a sugeroside through a ketal bond. An assay of cytotoxicity towards the lung adenocarcinoma (A549) cell line was performed. Among the compounds isolated, only diosmarioside D (4) and sugeroside 9 showed strong activity. The anti-microbial activity toward multi-drug resistant strains was also determined, but no activity was observed.

Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum

Descaudatine A (1), an undescribed phenolic glycoside, along with a known analogue (2) and ten flavonoids (3-12), were isolated from the whole plant of Desmodium caudatum. Compounds 1 and 4 exhibited potent antioxidant activities with the IC50 of 58.59 μM and 31.31 μM, respectively, which were approached to that of the positive control Vitamin C (IC50 = 46.32 μM). Meanwhile, 12 showed moderate antioxidant activity with the IC50 of 173.9 μM. Besides, compounds 3 and 6 inhibited the proliferation of HeLa cells with IC50 values of 56.14 μM and 69.04 μM, respectively. Further studies indicated that 3 and 6 could dose-dependently induce PARP cleavage and might trigger caspase-3, 8, 9 activation to induce apoptosis. RXRα is an ideal anticancer target of nuclear receptor. The reporter gene assay of RXRα indicated that 3 and 6 could inhibited the 9-cis-RA induced RXRα transcription in a concentration-dependent manner.

Two new coumarin glycosides from Chimonanthus nitens

Two new coumarin glycosides, namely nitensosides A-B (1-2), together with six known compounds, scopolin (3), 5,6,7-trimethoxycoumarin (4), d-calycanthine (5), calycanthoside (6), xeroboside (7), and scopoletin (8), were isolated from Chimonanthus nitens. The structures of the new compounds were elucidated by comprehensive analysis of IR, MS, and NMR spectroscopic data. Compounds 3, 4, 7, and 8 showed moderate inhibitory activity against Micrococcus luteus.

Chemical constituents from the leaves of Aglaia perviridis

A new cinnamic acid-derived bisamide 1 and a new oplopanone-type sesquiterpenoid diglycoside 2, together with 11 known compounds, were isolated from the 95% ethanolic extract of the leaves of Aglaia perviridis. Their structures were elucidated by chemical and spectroscopic methods.

Four new trace phenolic glycosides from Curculigo orchioides

Four new trace phenolic glycosides named orcinosides D (1), E (2), F (3), and G (4) were isolated from the rhizomes of Curculigo orchioides Gaertn. Based on comprehensive spectroscopic analyses including IR, FAB-MS, HR-ESI-MS, 1D- and 2D NMR (HSQC, HMBC),

Gout prophylactic constituents from the flower buds of Lonicera japonica

Two new sesquiterpene glycosides (R)-dehydroxyabscisic alcohol β-d-apiofuranosyl-(1″ → 6′)-β-d-glucopyranoside (1) and (-)-(1S,2R,6R,7R)-1,2,6-trimethyl-8-hydroxy methyltricyclic[5.3.1.02,6]-undec-8-en-10-one β-d-apiofuranosyl-(1″ → 6′)-β-d-glucopyranoside (2), were isolated from the flower buds of Lonicera japonica. Their structures were determined by spectroscopic and chemical methods. Compound 2 could significantly decrease monosodium urate-mediated cytokine production from activated macrophage through lowering IL-1β and TNFα.

A new phenolic glycoside and cytotoxic constituents from Celosia argentea

A new phenolic glycoside, 4-O β- D-apifuranosyl-(12) β- D-glucopyranosyl-2-hydroxy-6-methoxyacetophenone (2) and 11 known compounds were isolated from the MeOH extract of the plant Celosia argentea. The structures of the compounds were elucidated on the basis of spectroscopic analysis and chemical methods. Among the isolated compounds, stigmasterol (10) showed moderate inhibitory activities against SGC-7901 and BEL-7404 cells.