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CAS

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4294-26-2

Phenylalanylglycine, also known as Z-Phe-Gly or carbobenzoxy-L-phenylalanine glycine, is a dipeptide consisting of two amino acids, phenylalanine and glycine, linked together by a peptide bond. The phenylalanine amino acid is protected by a carbobenzoxy (Z) group, which is a temporary protecting group used in peptide synthesis to prevent unwanted side reactions. phenylalanylglycine is commonly used in the field of organic chemistry and peptide synthesis, particularly in the solid-phase peptide synthesis (SPPS) technique, where it serves as a building block for the formation of larger peptide chains. The Z group is later removed under mild acidic conditions to yield the desired peptide sequence. Phenylalanylglycine plays a crucial role in the development of pharmaceuticals, as it can be incorporated into various peptide drugs and therapeutics.

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  • 4294-26-2 Structure

  • Basic information

    1. Product Name: phenylalanylglycine
    2. Synonyms: phenylalanylglycine;Nsc89183
    3. CAS NO:4294-26-2
    4. Molecular Formula: C11H14N2O3
    5. Molecular Weight: 222.24
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 4294-26-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
    8. Solubility: Methanol (Slightly), Water (Sparingly, Sonicated)
    9. PKA: pK1:3.10(+1);pK2:7.71(0) (25°C,μ=0.01)
    10. Stability: Hygroscopic
    11. CAS DataBase Reference: phenylalanylglycine(CAS DataBase Reference)
    12. NIST Chemistry Reference: phenylalanylglycine(4294-26-2)
    13. EPA Substance Registry System: phenylalanylglycine(4294-26-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 4294-26-2(Hazardous Substances Data)

4294-26-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4294-26-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,9 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4294-26:
(6*4)+(5*2)+(4*9)+(3*4)+(2*2)+(1*6)=92
92 % 10 = 2
So 4294-26-2 is a valid CAS Registry Number.

4294-26-2Relevant articles and documents

Peptide Decomposition in the Neutral pH Region via the Formation of Diketopiperazines

Steinberg, Spencer M.,Bada, Jeffrey L.

, p. 2295 - 2298 (2007/10/02)

In the neutral pH region, the decomposition of the tripeptides Leu-Gly-Gly and Gly-Leu-Gly at 130 deg C and the hexapeptide Phe-Gly-Leu-Gly-Val-Gly at 100 deg C has been found to involve the formation of diketopiperazines from the N-terminal position of the peptides.

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