721-90-4

Basic information

• Product Name: H-PHE-GLY-OH
• Synonyms: PHE-GLY;L-PHENYLALANYLGLYCINE;H-PHE-GLY-OH;Phe-Gly hydrate;Phe-glycrystalline;L-Phe-Gly-OH;Phe-Gly-OH;2-[(2-amino-3-phenylpropanoyl)amino]acetic acid
• CAS NO: 721-90-4
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.24
• EINECS: 222-027-9
• Mol File: 721-90-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: ~260 °C (dec.)
• Boiling Point: 512.5°C at 760 mmHg
• Flash Point: 263.7°C
• Appearance: /
• Density: 1.259g/cm³
• Vapor Pressure: 2.51E-11mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: -15°C
• PKA: 3.13±0.10(Predicted)
• BRN: 2218143
• CAS DataBase Reference: H-PHE-GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-PHE-GLY-OH(721-90-4)
• EPA Substance Registry System: H-PHE-GLY-OH(721-90-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 721-90-4(Hazardous Substances Data)

Usage

Chemical Properties

White product

Definition

ChEBI: A dipeptide formed from L-phenylalanine and glycine residues.

InChI:InChI=1/C11H14N2O3/c12-9(11(16)13-7-10(14)15)6-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,16)(H,14,15)/t9-/m0/s1

Upstream product

• 56-40-6 L-Glycin 
• 583-47-1 L-Phenylalanin-N-carbonsaeureanhydrid 
• 30189-51-6 ethyl (N-tert-butoxycarbonyl-L-phenylalanyl)glycinate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 4294-26-2 phenylalanylglycine 
• 81917-69-3 N-(1-Benzotriazolylcarbonyl)-L-phenylalanin 
• 56-40-6 glycine 
• 105995-29-7 Ac-Ala-Gln-Phe-Gly-OH 
• 121574-55-8 Ac-Ala-DABA-Phe-Gly-OH 
• 103-72-0 phenyl isothiocyanate 
• 121574-56-9 Ac-Ala-DAPA-Phe-Gly-OH 
• 94779-07-4 HPheGlyOBn 
• 40719-52-6 N-[(S)-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-3-phenyl-propionyl]-glycine ethyl ester 
• 13122-99-1 (S)-2-(2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)acetic acid 

Downstream Products

• 62107-97-5 Phenylalanyl-glycinanhydrid 
• 10125-07-2 3-benzyl-piperazine-2,5-dione 
• 5037-75-2 cyclo(Gly-Phe) 
• 158513-54-3 Ts-Phe-Gly-O-(+)-Men 
• 158419-33-1 N-Ts-L-Phe-Gly-OMe 

Relevant articles and documents

A PROCESS FOR PREPARATION OF A PEPTIDE

The present invention relates to a novel process for preparation of peptides having amino acid chain length in the range of 2-40 comprises the steps: i) attaching an end-blocked amino acid with an ionic liquid based solid support in presence of an ionic solvent to obtain an end-terminal blocked amino acid attached ionic liquid; ii) removing end-terminal blocking agent from the end-terminal blocked amino acid attached ionic liquid of step i) followed by work up to obtain an amino acid attached ionic liquid; iii) repeating steps i) through ii) one or more times to obtain a polypeptide attached ionic liquid; and iv) detaching the polypeptide from the polypeptide attached ionic liquid of step iii) to obtain the polypeptide. Said process does not use any auxiliary reagents like dehydrating agent or activating agent. The use of ionic liquids as supports as well as solvents result in the faster kinetics of the process, the separation issues are reduced, and the process has no racemization issues.

Aggregation propensity of amyloidogenic and elastomeric dipeptides constituents

This study demonstrates the self-assembly of N- and C-terminal protected dipeptides Phe–Gly and Pro–Gly which were derived from amyloidogenic and elastomeric peptide sequences. These constituents afforded nanostructured supramolecular ensembles through va

N -boc deprotection and isolation method for water-soluble zwitterionic compounds

A highly efficient TMSI-mediated deprotection and direct isolation method to obtain zwitterionic compounds from the corresponding N-Boc derivatives has been developed. This method has been demonstrated in the final deprotection/isolation of the β-lactamase inhibitor MK-7655 as a part of its manufacturing process. Further application of this process toward other zwitterionic compounds, such as dipeptides and tripeptides, has been successfully developed. Furthermore, a catalytic version of this transformation has been demonstrated in the presence of BSA or BSTFA.