68882-99-5Relevant academic research and scientific papers
A Regiocontrolled Synthesis of Substituted Indoles by Palladium-Catalyzed Coupling of 2-Bromonitrobenzenes and 2-Bromoacetanilides
Kasahara, Akira,Izumi, Taeko,Murakami, Satoshi,Miyamoto, Kazuhiro,Hino, Toshimi
, p. 1405 - 1413 (2007/10/02)
The palladium-catalyzed cross-coupling reaction of 2-bromonitrobenzenes or 2-bromoacetanilides with ethylene has been used to produce a variety of substituted indoles.The mild reaction conditions and selectivity inherent in the coupling reaction have been utilized to produce regiochemically pure 4-, 5-, 6-, and 7-substituted indoles.
Ortho Vinylation of Aromatic Amides via Cyclopalladation Complexes
Horino, Hiroshi,Inoue, Naoto
, p. 4416 - 4422 (2007/10/02)
The reaction of acetanilide and meta- and para-substituted acetanilides with palladium acetate has given new ortho-palladated complexes 2a-j, which reacted with carbon monoxide, ethylene, or methyl vinyl ketone to produce the corresponding N-acylanthranilic esters 4a-m, 2-acetaminostyrenes 9k-p, and 4-aryl-3-buten-2-one derivatives 9a-j, respectively.Reactions of 2a with substituted olefins proceeded readily to give the 2-olefins 8a-h.Ortho-substituted acetanilides and N-methylacetanilide did not undergo complex formation with palladium acetate.
