42951-53-1

Basic information

• Product Name: 1H-Indole, 1-octyl-2-phenyl-
• CAS NO: 42951-53-1
• Molecular Formula: C22H27N
• Molecular Weight: 305.463
• Mol File: 42951-53-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 1-octyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 1-octyl-2-phenyl-(42951-53-1)
• EPA Substance Registry System: 1H-Indole, 1-octyl-2-phenyl-(42951-53-1)

Safety Data

• Hazardous Substances Data: 42951-53-1(Hazardous Substances Data)

Upstream product

• 111-86-4 n-Octylamine 
• 10271-57-5 1-chloro-2-(2-phenylethynyl)benzene 
• 615-41-8 2-iodochlorobenzene 
• 536-74-3 phenylacetylene 
• 21375-88-2 1-bromo-2-(phenylethenyl)benzene 
• 98-86-2 acetophenone 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 111-83-1 1-bromo-octane 
• 120-72-9 indole 
• 42951-63-3 1-octyl-1H-indole 
• 591-50-4 iodobenzene 

Downstream Products

• 132426-87-0 1,1-bis(1-n-octyl-2-phenylindole-3-yl)ethylene 

Relevant articles and documents

Efficient synthesis of 2-substituted indoles based on palladium(II) acetate/tri-tert-butylphosphine-catalyzed alkynylation/amination of 1,2-dihalobenzenes

A simple, efficient palladium(II) acetate/tri-tert-butylphosphine-catalyzed indole synthesis from o-alkynylhalobenzenes, readily available from 1,2-dihalobenzenes, has been achieved in good to excellent yields. A one-pot, Pd(OAc)2/t-Bu3P-catalyzed sequential reaction from 1-chloro-2-iodobenzene, phenylacetylene and amines has also been achieved in good yields.

Nickel-catalyzed, base-mediated amination/hydroamination reaction sequence for a modular synthesis of indoles

A catalytic system consisting of [Ni(cod)2] and ligand dppf enabled an efficient synthesis of differently substituted indoles through a modular reaction sequence, which consists of intermolecular aminations and intramolecular hydroaminations with ortho-alkynylhaloarenes.

General and efficient indole syntheses based on catalytic amination reactions

(Chemical Equation Presented) Highly flexible and efficient syntheses of the indole backbone are presented starting from o-alkynylhaloarenes. These transformations proceed via a palladium- or a copper-catalyzed amination reaction and a subsequent cyclization reaction in good to excellent yields. Furthermore, a multicatalytic one-pot indole synthesis starting from o-chloroiodobenzene is viable using a single catalyst consisting of an N-heterocyclic carbene palladium complex and Cul.