429684-95-7

Upstream product

• 1013658-51-9 (2S,5R)-5-(Dimethyl-phenyl-silanyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 916049-25-7 5-benzenesulfonylpyrrolidine-1,2-dicarboxylic acid 1-benzyl 2-methyl ester 
• 214072-10-3 (5S)-2-Methoxy-1-[(benzyloxy)carbonyl]-5-methoxycarbonylpyrrolidine 
• 133010-06-7 1,1-dimethylethyl S-N-(1-fluorocarbonyl-2-phenylethyl)carbamate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 916049-26-8 5-(dimethylphenylsilyl)pyrrolidine-1,2-dicarboxylic acid 1-benzyl 2-methyl ester 
• 916049-27-9 1-(2-tert-butoxycarbonylamino-3-phenylpropionyl)-5-(dimethylphenylsilyl)pyrrolidine-2-carboxylic acid methyl ester 
• 67-56-1 methanol 

Relevant academic research and scientific papers

Building functionalized peptidomimetics: Use of electroauxiliaries for introducing N-acyliminium ions into peptides

A series of silyl-substituted amino acids have been synthesized, inserted into peptides, and then employed as precursors for oxidatively generating reactive N-acyliminium ions. Both electrochemical and chemical oxidation procedures have been employed. N-Acyliminium ion generation in a solid-phase substrate as well as application to a small library of functionalized dipeptides has been demonstrated. Limitations in terms of how electron-rich the silyl groups can be as well as the compatibility of multiple silyl groups within a longer peptide are defined.

Silyl-Substituted Amino Acids: New Routes to the Construction of Selectively Functionalized Peptidomimetics

(matrix presented) Silylated amino acids have been incorporated into peptides and then converted into N-acyliminium ions with the use of an anodic oxidation reaction. The result is a method for selectively incorporating conformational constraints or exter