43010-64-6

Upstream product

• 67-56-1 methanol 
• 631-31-2 2-ethyl-2-methylsuccinic acid 
• 186581-53-3 diazomethane 
• 84590-14-7 2-Ethyl-2-methyl-3-methoxycarbonylpropionic Acid 
• 50598-33-9 2-ethyl-2-methylsuccinic anhydride 
• 82535-07-7 Dimethyl 2-allyl-2-ethylbutanedioate 
• 82484-89-7 (+/-)-Dimethyl 2-ethyl-2-(formylmethyl)succinate 

Downstream Products

• 124106-10-1 (S)-2-ethyl-2-methyl-eicosanoic acid methyl ester 
• 39122-19-5 ethosuximide 

Relevant academic research and scientific papers

SYNTHESIS OF 4,4- AND 5,5-DISUBSTITUTED 4,5-DIHYDRO-6H-CANTHIN-6-ONES

The paper describes regiospecific synthesis of 4,4- and 5,5-disubstituted 4,5-dihydro-6H-canthin-6-ones III and XVIII, starting from half-esters of 2,3-disubstituted succinic acids, V and XIV.The formation of the anomalous 5,5-disubstituted canthin-4,6-diones XVII is ascribed to oxidation of the intermediate XIX.The 1H NMR spectra of the compounds prepared are discussed.

ABSOLUTE CONFIGURATION OF (R)-(-)-2-ALLYL-2-ETHYL-3-METHOXYCARBONYLPROPIONIC ACID

The absolute configuration of (R)-(-)-2-allyl-2-ethyl-3-methoxycarbonylpropionic acid (I) was determined on the basis of the conversion of I to dimethyl (S)-(-)-2-ethyl-2-methylsuccinate (X) and (R)-(+)-4-ethyl-4-propyl-4,5-dihydro-6H-canthin-6-one (XIV).