631-31-2

Usage

Uses

2-Ethyl-2-methylsuccinic Acid is an inhibitor of plasmid-borne IMP-1 metallo-β-lactamase.

InChI:InChI=1/C7H12O4/c1-3-7(2,6(10)11)4-5(8)9/h3-4H2,1-2H3,(H,8,9)(H,10,11)/t7-/m1/s1

Upstream product

• 1795-47-7 2,3-dicyano-3-methyl-valeric acid ethyl ester 
• 861317-69-3 1-ethoxy-3-ethyl-3-methyl-cyclopropane-1,2-dicarboxylic acid 
• 7732-18-5 water 
• 52084-04-5 2-ethyl-3-methylsuccinic anhydride 
• 50598-33-9 2-ethyl-2-methylsuccinic anhydride 
• 50598-34-0 β-ethyl-β-methyl-γ-butyrolactone 
• 3552-33-8 2-ethyl-3-methylmaleic anhydride 
• 7664-93-9 sulfuric acid 
• 18424-76-5 dimethyl malonate sodium salt 
• 151-50-8 potassium cyanide 
• 872790-20-0 3-ethyl-3-methyl-4-oxo-valeric acid 
• 2654-72-0 2,5-dihydroxy-3,6-dimethyl-1,4-benzoquinone 
• 859182-48-2 1-(1-cyano-1-hydroxy-ethyl)-cyclopropanecarboxylic acid ethyl ester 
• 10034-85-2 hydrogen iodide 

Downstream Products

• 43010-64-6 Dimethyl (+/-)-2-ethyl-2-methylsuccinate 
• 50598-33-9 2-ethyl-2-methylsuccinic anhydride 
• 77-67-8 ethosuximide 
• 124106-10-1 (S)-2-ethyl-2-methyl-eicosanoic acid methyl ester 
• 160089-27-0 1-phenylamino-3-ethyl-3-methylpyrrolidine-2,5-dione 
• 1034317-09-3 C₁₃H₁₅ClN₂O₂ 
• 1034317-05-9 1-(4-methylphenylamino)-3-ethyl-3-methylpyrrolidine-2,5-dione 
• 1034317-04-8 1-(2-methylphenylamino)-3-ethyl-3-methylpyrrolidine-2,5-dione 
• 1034317-08-2 1-(3-chlorophenylamino)-3-ethyl-3-methylpyrrolidine-2,5-dione 
• 1034317-11-7 C₁₃H₁₅BrN₂O₂ 
• 1034317-07-1 1-(2-chlorophenylamino)-3-ethyl-3-methylpyrrolidine-2,5-dione 
• 1034317-10-6 C₁₃H₁₄Cl₂N₂O₂ 
• 1402547-06-1 C₁₈H₃₁N₃O₂ 

Relevant academic research and scientific papers

Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives

In the present study, twelve new 1-aryl-3-ethyl-3-methylpyrrolidine-2,5-diones were synthesized and their structures were characterized by FT-IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. In the final step of synthetic rout, condensation between corresponding succinic acid and substituted anilines has been improved using the microwave irradiation. Significantly higher yields compared to conventional condensation have been observed. The preliminary biological results indicated that some of the synthesized compounds showed promising in vitro antifungal activities towards several test fungi. 1-(4-Bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione (8) exhibited significant in vitro inhibitory activities against broad spectra of fungus, and on the basis of obtained data, the investigated bromo derivative has to be observed as novel potential fungicide. The density functional theory (DFT) calculations have been performed in order to study the structure-activity relationship (SAR) of the investigated molecules. In order to prediction of the chemical activity of the molecule, the molecular electrostatic potential (MEP) map was analyzed for the optimized geometry of 1-phenyl-3-ethyl-3-methylpyrrolidine-2,5-dione (4) and 1-(4-bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione (8).

Ni-Catalyzed Site-Selective Dicarboxylation of 1,3-Dienes with CO2

A site-selective catalytic incorporation of multiple CO2 molecules into 1,3-dienes en route to adipic acids is described. This protocol is characterized by its mild conditions, excellent chemo- and regioselectivity and ease of execution under CO2 (1 atm), including the use of bulk butadiene and/or isoprene feedstocks.