43019-64-3Relevant academic research and scientific papers
Alkali metal-hydroxide-catalyzed C(sp)-H Bond silylation
Toutov, Anton A.,Betz, Kerry N.,Schuman, David P.,Liu, Wen-Bo,Fedorov, Alexey,Stoltz, Brian M.,Grubbs, Robert H.
, p. 1668 - 1674 (2017)
Disclosed is a mild, scalable, and chemoselective catalytic cross-dehydrogenative C-H bond functionalization protocol for the construction of C(sp)-Si bonds in a single step. The scope of the alkyne and hydrosilane partners is substantial, providing an entry point into various organosilane building blocks and additionally enabling the discovery of a number of novel synthetic strategies. Remarkably, the optimal catalysts are NaOH and KOH.
