43029-70-5

Usage

Uses

Used in Pharmaceutical Industry:
4-HYDROXY-4'-METHYL-BIPHENYL-3-CARBOXYLIC ACID is used as a precursor for the synthesis of pharmaceuticals. Its unique structure allows it to be a building block for the development of new drugs, potentially leading to the creation of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 4-HYDROXY-4'-METHYL-BIPHENYL-3-CARBOXYLIC ACID is utilized as a starting material for the synthesis of various agrochemicals. Its properties make it suitable for the development of new pesticides or other agricultural chemicals that can improve crop protection and yield.
Used in Materials Science:
4-HYDROXY-4'-METHYL-BIPHENYL-3-CARBOXYLIC ACID is also used in materials science for the development of new materials. Its chemical properties can contribute to the creation of innovative materials with specific characteristics for various applications.
Used in Coordination Chemistry:
As a potential ligand for coordination chemistry, 4-HYDROXY-4'-METHYL-BIPHENYL-3-CARBOXYLIC ACID is employed in the synthesis of coordination compounds. These compounds have potential applications in areas such as catalysis, sensing, and medicinal chemistry.
Used in Medicinal and Biological Studies:
Due to its potential biological activity, 4-HYDROXY-4'-METHYL-BIPHENYL-3-CARBOXYLIC ACID is a molecule of interest for medicinal and biological studies. Researchers explore its interactions with biological systems to understand its potential therapeutic effects and applications in medicine.

Upstream product

• 89-55-4 5-bromosalicyclic acid 
• 15738-23-5 sodium tetrakis(4-tolyl)borate 
• 5720-05-8 4-methylphenylboronic acid 
• 321-14-2 5-chloro-2-hydroxybenzoic acid 

Relevant academic research and scientific papers

Green synthesis of biphenyl carboxylic acids via Suzuki–Miyaura cross-coupling catalyzed by a water-soluble fullerene-supported PdCl2 nanocatalyst

A green synthesis of variously substituted biphenyl carboxylic acids was achieved through Suzuki–Miyaura cross-coupling of a bromobenzoic acid with an aryl boronic acid using a water-soluble fullerene-supported PdCl2 nanocatalyst (C60-TEGs/ PdCl2). Yields of more than 90% were obtained at room temperature in 4 h using 0.05 mol% catalyst and 2 equiv. K2CO3.

A highly efficient catalyst of a nitrogen-based ligand for the Suzuki coupling reaction at room temperature under air in neat water

Glycine, as a kind of commercially available and inexpensive ligand, is used to prepare an air-stable and water-soluble catalyst for the Suzuki-Miyaura reaction in our study. In the presence of 0.1% [PdCl2(NH 2CH2COOH)2] as the catalyst, extremely excellent catalytic activity towards the Suzuki-Miyaura coupling of aryl halides containing the carboxyl group with various aryl boronic acids is observed at room temperature under air in neat water. the Partner Organisations 2014.

Palladium charcoal-catalyzed, ligandless Suzuki reaction by using tetraarylborates in water

In water and without using any ligand, palladium charcoal-catalyzed Suzuki coupling reaction of tetraarylborates with aryl bromides could be achieved in excellent yield. A concise mechanism consisting of four catalytic cycles is depicted in this paper.

Palladium-catalyzed biaryl-coupling reaction of arylboronic acids in water using hydrophilic phosphine ligands

Hydrophilic phosphine ligands possessing a carbohydrate side-chain, such as N-(4-diphenylphosphinophenyl)methyl gluconamide (9), N-[4-(2′-dicyclohexylphosphinobiphenyl)phenylmethyl] gluconamide (10), and N-[4-(2′-di-t-butylphosphinobiphenyl)]phenylmethyl gluconamide (11), were newly synthesized to carry out palladium-catalyzed biaryl coupling of arylboronic acids in a single aqueous medium. The catalyst prepared in situ from Pd(OAc)2 and 10 exhibited a higher efficiency than that of 9, 11, Ph2P(m-C6H4SO3Na) (TPPMS) or P(m-C6H4SO3Na)3 (TPPTS) for representative aryl bromides, chlorides, or triflates. The catalyst prepared in situ from Pd(OAc)2 (0.001mol%) and 10 (0.002mol%) achieved 96,000 TON in the reaction of p-tolylboronic acid with 4-bromoacetophenone in water.