4303-44-0Relevant academic research and scientific papers
REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS
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Paragraph 001143; 001152-001153, (2022/01/05)
The present disclosure provides compounds of Formula IA and Formula IB and their pharmaceutical compositions as selective agonists of REV-ERB-α: where R1, R2, R3, R4, R5, RX1, RX2, nA, nB, X, Y, and Z are described herein. The compounds are useful in various methods and uses, such as in the treatment of diseases including hyperglycemia, dyslipidemia, atherosclerosis, and autoimmune and inflammatory disorders or diseases, and as cancer therapeutics, such as for the treatment of glioblastoma, hepatocellular carcinoma, and colorectal cancer, and for immune-oncology purposes.
Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha
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Page/Page column 59, (2010/11/30)
The present application describes novel β-amino acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, Ua, Xa, Ya, Za, R1, R2, R3
SYNTHESIS OF POLYSULFIDES, SULFOXIDES AND SULFONES CONTAINING REACTIVE GROUPS
Aberkane, O.,Mieloszynski, J. L.,Robert, D.,Born, M.,Paquer, D.
, p. 245 - 256 (2007/10/02)
Preparation of polysulfides, sulfoxides and sulfones (containing reactive groups: OH, Cl, COOR, CN, SO3Na) are presented; 13C chemical shifts of these compounds have been recorded.Keywords: Sulfide; sulfoxide; sulfone; chlorosulfide; 1H NMR; 13C NMR.
2-iminobenzothiazoline derivatives, their preparation and pharmaceutical compositions containing them
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, (2008/06/13)
Compounds of the formula: STR1 in which - R1 denotes a polyfluoroalkoxy or polyfluoroalkyl radical, and - R2 denotes either a chain --CH2 --(CH(R4))n --R3, in which R3 denotes a dialkylamino, piperidino, 1-pyrrolidinyl, mercapto, acylthio, alkylthio, alkylsulphinyl or alkylsulphonyl radical, R4 denotes a hydrogen atom or an alkyl radical and n is equal to 0 or 1, or a residue of formula: STR2 the said alkyl and alkoxy radicals and portions containing 1 to 4 carbon atoms each in a straight or branched chain and said the acyl portions containing 2 to 4 carbon atoms each, and the salts of these compounds, are useful in the treatment of diseases in which glutamate is implicated.
