43032-69-5

Basic information

• Product Name: 3-TRIFLUOROMETHYLPHENYLMETHYLSULFONE
• Synonyms: 3-TRIFLUOROMETHYLPHENYLMETHYLSULFONE;1-METHANESULFONYL-3-TRIFLUOROMETHYL-BENZENE
• CAS NO: 43032-69-5
• Molecular Formula: C₈H₇F₃O₂S
• Molecular Weight: 224.2
• Mol File: 43032-69-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 67-69°C
• Boiling Point: 305.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.361±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-TRIFLUOROMETHYLPHENYLMETHYLSULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-TRIFLUOROMETHYLPHENYLMETHYLSULFONE(43032-69-5)
• EPA Substance Registry System: 3-TRIFLUOROMETHYLPHENYLMETHYLSULFONE(43032-69-5)

Safety Data

• Hazardous Substances Data: 43032-69-5(Hazardous Substances Data)

Usage

Description

3-Trifluoromethylphenylmethylsulfone is a chemical compound with the molecular formula C8H7F3O2S. It is a sulfone derivative featuring a trifluoromethylphenylmethyl group attached to the sulfur atom. 3-TRIFLUOROMETHYLPHENYLMETHYLSULFONE is known for its unique properties, which make it a valuable reagent in various chemical reactions and a building block in organic synthesis and pharmaceutical research.

Uses

Used in Pharmaceutical Research:
3-Trifluoromethylphenylmethylsulfone is utilized as a building block in the development of new drugs. Its trifluoromethyl group is particularly valuable in medicinal chemistry, as it can enhance the biological activity and pharmacokinetic properties of pharmaceutical compounds, leading to improved drug efficacy and safety.
Used in Organic Synthesis:
3-TRIFLUOROMETHYLPHENYLMETHYLSULFONE serves as a key intermediate in organic synthesis, contributing to the creation of a wide range of chemical products. Its presence in reactions can influence the outcome, making it a versatile component in the synthesis of various organic compounds.
Used in Specialty Chemicals and Materials:
3-Trifluoromethylphenylmethylsulfone is also employed in the synthesis of specialty chemicals and materials. Its unique properties allow it to be a useful reagent in a variety of chemical reactions, contributing to the development of innovative and specialized products across different industries.

Upstream product

• 98-08-8 α,α,α-trifluorotoluene 
• 7143-01-3 Methanesulfonic anhydride 
• 20277-69-4 sodium methansulfinate 
• 98-15-7 3-chlorotrifluoromethylbenzene 
• 672-58-2 3-(trifluoromethyl)benzenesulfonamide 
• 74-88-4 methyl iodide 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 80-58-0 2-Bromobutyric acid 
• 777-44-6 3-(Trifluoromethyl)benzenesulfonyl chloride 

Downstream Products

• 1044271-87-5 1-(methylsulfonyl)-3-nitro-5-(trifluoromethyl)benzene 
• 1403946-31-5 C₂₅H₂₈F₃N₃O₃S 

Relevant articles and documents

Primary Sulfonamide Functionalization via Sulfonyl Pyrroles: Seeing the N?Ts Bond in a Different Light

Despite common occurrence in molecules of value, methods for transforming sulfonamides are distinctly lacking. Here we introduce easy-to-access sulfonyl pyrroles as synthetic linchpins for sulfonamide functionalization. The versatility of the sulfonyl pyrrole unit is shown by generating a variety of products through chemical, electrochemical and photochemical pathways. Preliminary results on the direct functionalization of primary sulfonamides are also provided, which may lead to new modes of activation.

A New Class of Amide Ligands Enable Cu-Catalyzed Coupling of Sodium Methanesulfinate with (Hetero)aryl Chlorides

((2S,4R)-4-Hydroxy-N-(2-methylnaphthalen-1-yl)pyrrolidine-2-carboxamide (HMNPC), an amide derived from 4-hydroxy-L-proline and 2-methyl naphthalen-1-amine, is a powerful ligand for Cu-catalyzed coupling of (hetero)aryl halides with sulfinic acid salts, allowing for first time the metal-catalyzed coupling of (hetero)aryl chlorides and NaSO2Me. A considerable number of (hetero)aryl chlorides worked well, providing the pharmaceutically important (hetero)aryl methylsulfones in good to excellent yields.

Pteridinone derivatives as PI3-kinases inhibitors

New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.