43039-99-2

Usage

Structure

Thiophene ring attached to a propanone group

Physical State

Pale yellow liquid

Odor

Strong

Usage

Precursor in the synthesis of pharmaceuticals and agrochemicals

Properties

Mutagenic and carcinogenic

Health Risks

Irritation to skin, eyes, and respiratory system

Safety Precautions

Handle and store with caution, follow proper safety protocols to minimize harmful effects

Upstream product

• 60-29-7 diethyl ether 
• 19432-64-5 2-thienylmagnesium chloride 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 676-58-4 methylmagnesium chloride 
• 1918-78-1 2-methylthiophene-3-carboxylic acid 

Downstream Products

• 13657-90-4 3-acetylthiophene-2-carboxylic acid 

Relevant academic research and scientific papers

HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND

A novel α-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided. A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; R1 is the same or different, and represents a halogen atom, or a C1-C3 alkyl group; R2 represents a hydrogen atom, or a C1-C6 alkyl group; p represents an integer of 0 to 5; V represents CR3 wherein R3 represents a hydrogen atom, an amino group, a nitro group, or a C1-C3 alkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.

PROCESS FOR THE PRODUCTION OF INTERMADIATES FOR THE PREPARATION OF TRICYCLIC BENZIMIDAZOLES

The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.