430461-56-6

Basic information

• Product Name: R)-3-PHENYL PIPERIDINE
• Synonyms: (3R)-3-phenyl-Piperidine;Piperidine, 3-phenyl-, (3R)-
• CAS NO: 430461-56-6
• Molecular Formula: C₁₁H₁₅N
• Molecular Weight: 161.247
• Mol File: 430461-56-6.mol

Chemical Properties

• Melting Point: 179-181℃
• Boiling Point: 263.183 °C at 760 mmHg
• Flash Point: 115.488 °C
• Appearance: /
• Density: 0.967 g/cm³
• Vapor Pressure: 0.0104mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.01±0.10(Predicted)
• CAS DataBase Reference: R)-3-PHENYL PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: R)-3-PHENYL PIPERIDINE(430461-56-6)
• EPA Substance Registry System: R)-3-PHENYL PIPERIDINE(430461-56-6)

Safety Data

• Hazardous Substances Data: 430461-56-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-3-PHENYL PIPERIDINE is used as a building block for the synthesis of various medications, contributing to the development of new pharmaceuticals with improved therapeutic properties.
Used in Organic Compounds Synthesis:
(R)-3-PHENYL PIPERIDINE is used as a key intermediate in the production of organic compounds, enhancing their structural and functional characteristics.
Used in Agrochemicals Production:
(R)-3-PHENYL PIPERIDINE is utilized as a crucial component in the synthesis of agrochemicals, aiding in the development of effective and environmentally friendly products for agricultural applications.
Used in Research and Development:
(R)-3-PHENYL PIPERIDINE is employed as a starting material for the synthesis of new chemical entities, driving innovation and advancement in various scientific and industrial fields.

InChI:InChI=1/C11H15N/c1-2-5-10(6-3-1)11-7-4-8-12-9-11/h1-3,5-6,11-12H,4,7-9H2/t11-/m0/s1

Upstream product

• 56613-80-0 D-2-phenylglycinol 
• 343947-52-4 methyl 5-oxo-4-phenylpentanoate 
• 121440-71-9 ethyl (E)-1,3-diphenyl-2-propen-1-yl carbonate 
• 100-58-3 phenylmagnesium bromide 
• 58879-07-5 N-benzyl-3-hydroxy-3-phenylpiperidine 
• 40114-49-6 1-benzyl-3-piperidone 
• 100-59-4 phenylmagnesium chloride 
• 3979-67-7 N-benzyl-3-phenylpiperidine 
• 3973-62-4 3-phenylpiperidine 
• 430461-23-7 (3R,8R,8aR)-3,8-diphenyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 122-78-1 phenylacetaldehyde 
• 332-15-0 1-(2-phenylethynyl)piperidine 
• 4663-33-6 1,3-diphenyl-3-hydroxypropene 
• 917810-87-8 Allyl-((E)-(R)-2,4-diphenyl-but-3-enyl)-carbamic acid benzyl ester 

Downstream Products

• 1246348-51-5 3-(4-hydroxy-1H-pyrazolo[4,3-c]pyridin-3-yl)-1-((R)-3-phenyl-piperidin-1-yl)-propan-1-one 
• 1602922-51-9 (4-chlorophenyl)-carbamic acid (S)-2,2,2-trifluoro-1-((R)-3-phenylpiperidin-1-ylmethyl)-ethyl ester hydrochloride 
• 1448668-35-6 C₃₂H₃₆N₂O₃ 
• 1448667-87-5 (2'S,3R,4'S)-1^,-(2,2-diphenylacetyl)-3-phenyl-[1,4'-bipiperidine]-2'-carboxylic acid 
• 1448668-32-3 C₃₂H₃₆N₂O₃ 
• 1448667-86-4 (2'S,3R,4'R)-1^,-(2,2-diphenylacetyl)-3-phenyl-[1,4'-bipiperidine]-2'-carboxylic acid 
• 1446654-10-9 C₃₁H₃₄N₂O₃ 
• 1367871-86-0 (R)-3-(4-(cyclohexyloxy)-1H-pyrazolo[4,3-c]pyridin-3-yl)-1-(3-phenylpiperidin-1-yl)propan-1-one 
• 1367871-81-5 (R)-1-(3-phenylpiperidin1-yl)-3-(4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridin-3-yl)propan-1-one 
• 957113-13-2 C₃₇H₄₈FN₃O₆ 

Relevant articles and documents

Synthesis method for (R)-3-phenylpiperidine or/and (S)-3-phenylpiperidine and synthesis method for chiral intermediate of niraparib

The invention belongs to the technical field of organic synthesis. The synthesis method firstly provided by the invention takes benzyl-4-oxopiperidine as a starting material, and the starting materialis subjected to Grignard reaction, elimination reaction, hydrogenation reduction reaction and chiral resolution in sequence to successfully obtain a target product (R)-3-phenylpiperidine or/ and (S)-3-phenylpiperidine. The synthesis method sencondly provided by the invention takes the same starting raw material for Grignard reaction, organic silicon reagent is used for removing a hydroxide radical, and benzyl is removed by catalytic hydrogenation reaction; finally, the chiral resolution is carried out to obtain a target product. The (S)-3-phenylpiperidine can be synthesized according to the synthesis method. (S)-3-p-aminosalicylic phenylpiperidine can be synthesized according to the third aspect; or according to the fourth aspect, (S)-3-p-bromophenyl piperidine is synthesized to serve asthe key intermediate for preparing the niraparib. According to the synthesis method for (R)-3-phenylpiperidine or/ and (S)-3-phenylpiperidine and the synthesis method for chiral intermediate of niraparib, production cost is obviously lowered, and the synthesis methods are favorable for the large-scale industrial production of a niraparib medicine.

Pd-catalyzed asymmetric allylic alkylation with nitromethane using a chiral diaminophosphine oxide: (S,RP)-Ph-DIAPHOX. Enantioselective synthesis of (R)-preclamol and (R)-baclofen

A Pd-catalyzed asymmetric allylic alkylation with nitromethane using an aspartic acid-derived P-chirogenic diaminophosphine oxide [(S,RP)-Ph-DIAPHOX] is described. This method was successfully applied to enantioselective synthesis of (R)-precla

Dynamic kinetic resolution of racemic γ-aryl-δ-oxoesters. Enantioselective synthesis of 3-arylpiperidines

Cyclodehydration of racemic γ-aryl-δ-oxoesters with (R)- or (S)-phenylglycinol stereoselectively affords bicyclic δ-lactams, in a process that involves a dynamic kinetic resolution. Subsequent reduction of these lactams leads to enantiopure 3-arylpiperidines. Starting from racemic aldehyde esters, this short sequence has been applied to the synthesis of (R)-3-phenylpiperidine and the antipsychotic drug (-)-3-PPP (an (S)-3-arylpiperidine), whereas starting from racemic ketone esters enantiopure cis-2-alkyl-3-arylpiperidines are prepared.

Dynamic kinetic resolution and desymmetrization of enantiotopic groups by cyclodehydration of racemic or prochiral δ-oxoesters with (R)-phenylglycinol: Enantioselective synthesis of piperidines

Enantiotopic ester groups are desymmetrized in the cyclodehydration of prochiral δ-oxodiesters with (R)-phenylglycinol. This reaction can be extended to racemic δ-oxodiesters, which undergo a tandem dynamic kinetic resolution-diastereoselective differentiation process (see scheme). The resulting bicyclic lactams can be used in the preparation of a variety of synthetically and pharmacologically interesting enantiopure piperidine derivatives.