75868-48-3

Usage

Uses

21-Desacetoxy-21-Chloro Anecortave has been used in the preparation of pregnane derivatives.

Upstream product

• 104080-00-4 21-chloro-17-formyloxy4,9⁽¹¹⁾-pregnadiene-3,20-dione 
• 113752-83-3 17-hydroxy-11α,21-bis-methanesulfonyloxy-pregn-4-ene-3,20-dione 

Downstream Products

• 7753-60-8 anecortave 
• 50-23-7 HYDROCORTISONE 
• 5106-48-9 17-acetoxy-pregna-4,9⁽¹¹⁾-diene-3,20-dione 
• 641-77-0 21-deoxycortisol 
• 34184-82-2 pregna-4,9⁽¹¹⁾-diene-3,20-dione-17-hydroxy-21-methyl 
• 1882-82-2 17-hydroxy-pregn-4-ene-3,11,20-trione 
• 356-12-7 fluocinonide 
• 4306-83-6 21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione 

Relevant academic research and scientific papers

17β-cyano-9α,17α-dihydroxyandrost-4-en-3-one

The invention is the compound 17β-cyano-9α, 17α-dihydroxyandrost-4-en-3-one (I) which is particularly useful as an intermediate in the production of the 17α-halo silyl ethers (II).

17 α-chloroethynyl pregnane derivatives

Known pregnane derivatives are prepared by esterificiation of known androstane derivatives to give new ester of Formula III STR1 wherein in each case symbolizes a single bond or a double bond, n is 1 or 2, R1 is hydrogen or methyl, R2 is hydrogen or formyl, and R3 is chlorine, hydroxy or an alkanoyloxy group of up to 6 carbon atoms, and reaction of the latter with Ag(I) and formic acid.

Metallated halogenated acetylene corticoid synthesis

A process for the preparation of corticoids (IX) which comprises reacting a 17-keto steroid (I) with a metallated halogenated acetylene (II) followed by reaction with a sulfenylating agent (IV) and C17 side chain rearrangement.

Preparation of corticoids from 17-keto steroids

A process for the preparation of corticoids (XI) which comprises reacting a protected 17-keto steroid (II) with a metallated 1,2-dihaloethene (III).