63843-83-4

Basic information

• Product Name: 1-benzyl-4-phenylpiperidin-4-ol
• Synonyms: 1-Benzyl-4-Hydroxy-4-phenylpiperidine;4-phenyl-1-(phenylmethyl)piperidin-4-ol;4-Piperidinol, 4-phenyl-1-(phenylMethyl)-
• CAS NO: 63843-83-4
• Molecular Formula: C₁₈H₂₁NO
• Molecular Weight: 267.36544
• EINECS: 264-512-8
• Mol File: 63843-83-4.mol
• Article Data: 17

Chemical Properties

• Melting Point: 107-109℃
• Boiling Point: 425.4 °C at 760 mmHg
• Flash Point: 133.9 °C
• Appearance: /
• Density: 1.135
• Vapor Pressure: 5.39E-08mmHg at 25°C
• Refractive Index: 1.611
• PKA: 14.06±0.20(Predicted)
• CAS DataBase Reference: 1-benzyl-4-phenylpiperidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-phenylpiperidin-4-ol(63843-83-4)
• EPA Substance Registry System: 1-benzyl-4-phenylpiperidin-4-ol(63843-83-4)

Safety Data

• Hazardous Substances Data: 63843-83-4(Hazardous Substances Data)

Usage

General Description

1-Benzyl-4-phenylpiperidin-4-ol, also known as BPPO, is a chemical compound with potential psychoactive and analgesic properties. It is a piperidine derivative and a close analog of the opioid analgesic drug pethidine. BPPO is structurally similar to pethidine, but it lacks the N-methyl group found in pethidine. Research on BPPO is limited, but preliminary studies suggest that it may have similar effects to pethidine, including pain relief and potential central nervous system depressant properties. However, more research is needed to fully understand the pharmacological effects and potential therapeutic uses of this compound. Additionally, BPPO has the potential for abuse and dependence, and its use should be carefully monitored in a controlled medical setting.

InChI:InChI=1/C18H21NO/c20-18(17-9-5-2-6-10-17)11-13-19(14-12-18)15-16-7-3-1-4-8-16/h1-10,20H,11-15H2

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 591-51-5 phenyllithium 
• 76-84-6 triphenylmethyl alcohol 
• 100-58-3 phenylmagnesium bromide 
• 108-86-1 bromobenzene 
• 591-50-4 iodobenzene 
• 41661-47-6 piperidin-4-one 
• 40807-61-2 4-hydroxy-4-phenylpiperidin 
• 100-39-0 benzyl bromide 
• 100-59-4 phenylmagnesium chloride 
• 41979-39-9 4-piperidone hydrochloride 
• 5004-94-4 4-hydroxy-4-phenylpiperidine hydrochloride 
• 50-00-0 formaldehyd 
• 3287-99-8 benzylamine hydrochloride 

Downstream Products

• 94909-63-4 propionic acid-(1-benzyl-4-phenyl-[4]piperidyl ester) 
• 40807-61-2 4-hydroxy-4-phenylpiperidin 
• 172733-78-7 N-(1-benzyl-4-phenylpiperidin-4-yl)acetamide 
• 400770-91-4 4‐fluoro‐4‐phenylpiperidine 
• 1274933-90-2 1-benzyl-4-fluoro-4-phenyl-piperidine 
• 771-99-3 4-phenylpiperidine 
• 94163-98-1 1-benzyl-4-phenyl-1,2,5,6-tetrahydropirydine hydrochloride 
• 10272-49-8 4-phenylpiperidine hydrochloride 
• 43064-12-6 1,2,3,6-tetrahydro-4-phenylpyridine hydrochloride 
• 1333494-98-6 N-((S)-2-amino-3-((S)-1-((S)-1-((2S,3R)-4-(1-benzyl-4-phenylpiperidin-4-ylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-ylamino)-3-cyclohexyl-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide 
• 1333494-97-5 N-((S)-2-amino-3-((S)-1-((S)-1-((2S,3R)-4-(1-benzyl-4-phenylpiperidin-4-ylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-ylamino)-4-methyl-1-oxopentan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-2,5-dihydroxybenzamide 
• 1333494-96-4 N-((S)-2-amino-3-((S)-1-((S)-1-((2S,3R)-4-(1-benzyl-4-phenylpiperidin-4-ylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-ylamino)-3-cyclohexyl-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide 

Relevant articles and documents

Shuttle arylation by Rh(I) catalyzed reversible carbon–carbon bond activation of unstrained alcohols

The advent of transfer hydrogenation and borrowing hydrogen reactions paved the way to manipulate simple alcohols in previously unthinkable manners and circumvented the need for hydrogen gas. Analogously, transfer hydrocarbylation could greatly increase the versatility of tertiary alcohols. However, this reaction remains unexplored because of the challenges associated with the catalytic cleavage of unactivated C–C bonds. Herein, we report a rhodium(I)-catalyzed shuttle arylation cleaving the C(sp2)–C(sp3) bond in unstrained triaryl alcohols via a redox-neutral β-carbon elimination mechanism. A selective transfer hydrocarbylation of substituted (hetero)aryl groups from tertiary alcohols to ketones was realized, employing benign alcohols as latent C-nucleophiles. All preliminary mechanistic experiments support a reversible β-carbon elimination/migratory insertion mechanism. In a broader context, this novel reactivity offers a new platform for the manipulation of tertiary alcohols in catalysis.

CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS

The present invention provides cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway along with their use in therapeutic applications as described herein.

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists

Melanin concentrating hormone (MCH) is an important mediator of energy homeostasis and plays a role in metabolic and CNS disorders. The modeling-supported design, synthesis and multi-parameter optimization (biological activity, solubility, metabolic stability, hERG) of novel quinazoline derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss with a lead compound from this series is exemplified. Clusters of refined hMCHR1 homology models derived from the X-ray structure of the β2-adrenergic receptor, including extracellular loops, were developed and used to guide the design.