38025-45-5

Basic information

• Product Name: 1-BENZYL-1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE
• Synonyms: 1-BENZYL-1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE;1-Benzyl-4-phenyl-1,2,5,6-tetrahydropyridine
• CAS NO: 38025-45-5
• Molecular Formula: C₁₈H₁₉N
• Molecular Weight: 249.35
• Mol File: 38025-45-5.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BENZYL-1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE(38025-45-5)
• EPA Substance Registry System: 1-BENZYL-1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE(38025-45-5)

Safety Data

• Hazardous Substances Data: 38025-45-5(Hazardous Substances Data)

Usage

General Description

1-BENZYL-1,2,3,6-TETRAHYDRO-4-PHENYLPYRIDINE, also known as Etifoxine, is a synthetic compound with anxiolytic and anticonvulsant properties. It acts as a positive allosteric modulator of the GABAA receptor, enhancing the effects of the neurotransmitter GABA and leading to anxiolytic and sedative effects. Etifoxine is used for the treatment of anxiety disorders and is also being investigated for its potential in the treatment of neuropathic pain and alcohol withdrawal syndrome. It has been found to be well-tolerated and effective in clinical trials, making it a promising candidate for the management of various neurological and psychiatric conditions.

Upstream product

• 63843-83-4 1-benzyl-4-hydroxy-4-phenylpiperidine 
• 108-86-1 bromobenzene 
• 126781-38-2 1-benzyl-4-(trifluoromethylsulfonyloxy)-1,2,5,6-tetrahydropyridine 
• 100-58-3 phenylmagnesium bromide 
• 939-23-1 p-phenylpyridine 
• 100-39-0 benzyl bromide 
• 89290-93-7 1-Benzyl-4-phenyl-pyridinium; bromide 
• 936231-00-4 1-benzyl-4-(benzyldimethylsilanyl)-1,2,3,6-tetrahydro-pyridine 
• 591-50-4 iodobenzene 
• 50-00-0 formaldehyd 
• 107301-61-1 N-benzyl-4-amino-1-butyne 
• 98-80-6 phenylboronic acid 
• 10338-69-9 1,2,3,6-tetrahydro-4-phenylpyridine 
• 100-52-7 benzaldehyde 

Downstream Products

• 19015-37-3 1-(phenylmethyl)-4-phenylpiperidine 
• 94163-98-1 1-benzyl-4-phenyl-1,2,5,6-tetrahydropirydine hydrochloride 
• 10272-49-8 4-phenylpiperidine hydrochloride 
• 43064-12-6 1,2,3,6-tetrahydro-4-phenylpyridine hydrochloride 
• 474925-46-7 1-benzyl-3-hydroxy-4-phenyl-piperidine 
• 75527-48-9 1-ethoxycarbonyl-4-phenyl-3,4-epoxypiperidine 
• 75527-50-3 1-ethoxycarbonyl-3-formyl-3-phenylpyrrolidine 
• 75527-61-6 (1-Methyl-3-phenyl-pyrrolidin-3-yl)-acetyl chloride 
• 75527-59-2 (1-Methyl-3-phenyl-pyrrolidin-3-yl)-acetic acid 
• 75527-57-0 1-methyl-3-cyanomethyl-3-phenylpyrrolidine 
• 75527-55-8 1-methyl-3-chloromethyl-3-phenylpyrrolidine 
• 20538-35-6 1-methyl-3-hydroxymethyl-3-phenylpyrrolidine 
• 771-99-3 4-phenylpiperidine 
• 4600-95-7 1-ethoxycarbonyl-4-phenyl-1,2,5,6-tetrahydropyridine 

Relevant articles and documents

Synthetic method of 4 -phenyl piperidine hydrochloride

The invention discloses a synthesis method of 4 -phenylpiperidine hydrochloride, and the route is as shown in the specification. The method has the advantages of cheap and easily available raw materials, simple operation and post-treatment, high yield, high product purity and the like, and is suitable for industrial production.

CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS

The present invention provides cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway along with their use in therapeutic applications as described herein.

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists

A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein.