43073-13-8Relevant academic research and scientific papers
Identification of Potential Off-target Toxicity Liabilities of Catechol-O-methyltransferase Inhibitors by Differential Competition Capture Compound Mass Spectrometry
Von Kleist, Lisa,Michaelis, Simon,Bartho, Kathrin,Graebner, Olivia,Schlief, Marén,Dreger, Mathias,Schrey, Anna K.,Sefkow, Michael,Kroll, Friedrich,Koester, Hubert,Luo, Yan
, p. 4664 - 4675 (2016)
Structurally related inhibitors of a shared therapeutic target may differ regarding potential toxicity issues that are caused by different off-target bindings. We devised a differential competition capture compound mass spectrometry (dCCMS) strategy to ef
NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE
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Page/Page column 18; 20, (2017/07/06)
The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R1 is -OH, R2 is -NO2 and R3 is H, R4 and R5
