431079-79-7

Usage

Uses

Used in Pharmaceutical Industry:
1-tert-Butyl 3-methyl 2-oxopyrrolidine-1,3-dicarboxylate is used as a cognitive enhancer and nootropic agent for the treatment of cognitive disorders and dementia. Its application is based on its believed ability to modulate neurotransmitter levels in the brain, enhance cerebral blood flow, and improve glucose utilization, which collectively contribute to improved cognitive function.
Used in Dietary Supplements:
In the dietary supplement industry, 1-tert-Butyl 3-methyl 2-oxopyrrolidine-1,3-dicarboxylate is incorporated into formulations designed to support and enhance cognitive performance. Its inclusion in these supplements is due to its potential to provide cognitive benefits, making it a popular choice for those seeking to improve memory, learning, and overall brain health.

Upstream product

• 85909-08-6 tert-butyl 2-oxopyrrolidine-1-carboxylate 
• 79-22-1 methyl chloroformate 
• 616-45-5 2-pyrrolidinon 
• 24424-99-5 di-tert-butyl dicarbonate 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 1039756-11-0 1-tert-butyl 3-methyl 2-oxo-3-((mesitylsulfonamido)ethyl)pyrrolidine-1,3-dicarboxylate 
• 1397496-03-5 1-tert-butyl 3-methyl 3-(3,4-dihydroxy-5-methoxyphenyl)-2-oxopyrrolidine-1,3-dicarboxylate 
• 1397495-98-5 1-tert-butyl 3-methyl 3-(3,4-dihydroxyphenyl)-2-oxopyrrolidine-1,3-dicarboxylate 
• 1397496-01-3 1-tert-butyl 3-methyl 3-(3,4-dihydroxy-5-methylphenyl)-2-oxo-pyrrolidine-1,3-dicarboxylate 
• 1397496-06-8 C₁₈H₂₃NO₇ 
• 1240791-69-8 tert-butyl 3-[benzyl(penta-3,4-dien-1-yl)carbamoyl]-2-oxopyrrolidine-1-carboxylate 
• 431079-83-3 4-{[but-3-ynyl-(toluene-4-sulfonyl)-amino]-methyl}-2,3-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Compounds of Formula (0), Formula (I), and Formula (II) and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION

This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

SUBSTITUTED PYRAZOLE COMPOUNDS AS SERINE PROTEASE INHIBITORS

There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin and/or kallikrein, which compounds include substituted pyrazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which diseases or disorders are amenable to treatment or prevention by the inhibition of thrombin and/or kallikrein.

Total synthesis of (±)-powelline and (±)-buphanidrine

Chemical Equation Presented The total synthesis of (±)-powelline (13 linear steps in an overall yield of 6%) and (±)-buphanidrine (14 linear steps and a 6% overall yield) and has been achieved using a novel approach to the crinane skeleton. An organocatalytic oxidative coupling allowed direct construction of the key quaternary carbon-to-aryl bond in high yield allowing rapid access to the target alkaloids.

An oxidative coupling for the synthesis of arylated quaternary stereocentres and its application in the total synthesis of powelline and buphanidrine

Catechol derivatives directly bonded to all-carbon quaternary stereocentres are prevalent in nature. An oxidative coupling strategy for the synthesis of this motif is described. Pivoting on the base-catalysed Michael addition of carbon-centred pro-nucleop

Efficient base catalyzed alkylation reactions with aziridine electrophiles

N-Mesitylene sulfonyl and N-tosyl aziridines have been identified as effective electrophiles in alkylation reactions of carbon acids catalyzed by the organic phosphorine base BEMP; yields of up to 99% for a range of pro-nucleophiles under mild reaction co

Stereoselective synthesis of the tricyclic core ABC-rings of nakadomarin and manzamine from a common intermediate

Pauson-Khand cyclization of the enamide 9 proceeds in trifluoroethanol to give cyclopentenone 10, which on hydrogenation gives 11, having the core ABC-rings of nakadomarin 1.