43142-76-3

Basic information

• Product Name: 5-CHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: ETHYL 5-CHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE;IFLAB-BB F2113-0049;5-CHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER
• CAS NO: 43142-76-3
• Molecular Formula: C₁₂H₁₀ClNO₃
• Molecular Weight: 251.67
• Product Categories: pharmacetical
• Mol File: 43142-76-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 458°Cat760mmHg
• Flash Point: 230.8°C
• Appearance: /
• Density: 1.399g/cm³
• Vapor Pressure: 1.42E-08mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.60±0.30(Predicted)
• CAS DataBase Reference: 5-CHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER(43142-76-3)
• EPA Substance Registry System: 5-CHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER(43142-76-3)

Safety Data

• Hazardous Substances Data: 43142-76-3(Hazardous Substances Data)

Usage

General Description

5-CHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER is a chemical compound with the molecular formula C13H10ClNO3. It is an ethyl ester derivative of 5-chloro-3-formyl-1H-indole-2-carboxylic acid and is commonly used in organic synthesis and pharmaceutical research. 5-CHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER is known for its potential pharmacological activities and is being studied for its anti-inflammatory, antiviral, and antitumor properties. It is an important intermediate in the synthesis of various bioactive molecules and is a valuable tool for the development of new drug candidates. Additionally, this compound may also have potential applications in the dye, pigment, and material science industries.

InChI:InChI=1/C12H10ClNO3/c1-2-17-12(16)11-9(6-15)8-5-7(13)3-4-10(8)14-11/h3-6,14H,2H2,1H3

Upstream product

• 1073-69-4 N-4-chlorophenylhydrazine 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 5296-86-6 2-[(4-chlorophenyl)-hydrazono]-propionic acid ethyl ester 
• 4792-67-0 5-chloro-indole-2-carboxylic acid ethyl ester 
• 68-12-2 N,N-dimethyl-formamide 
• 107-06-2 1,2-dichloro-ethane 
• 93-61-8 N-methyl-N-phenylformamide 
• 127-09-3 sodium acetate 

Downstream Products

• 1040379-46-1 C₁₈H₁₃Cl₃N₂O₂ 
• 1040379-43-8 C₁₈H₁₄Cl₂N₂O₂ 
• 1040379-45-0 C₁₉H₁₇ClN₂O₃ 
• 1040379-42-7 C₁₈H₁₅ClN₂O₂ 
• 1040379-49-4 C₁₈H₁₅ClN₂O₃ 
• 1040379-48-3 C₁₉H₁₇ClN₂O₃ 
• 1040379-44-9 C₁₈H₁₄ClFN₂O₂ 
• 885273-63-2 (E)-3-(5-chloro-2-(ethoxycarbonyl)-1H-indol-3-yl)acrylic acid 
• 16382-20-0 5-chloro-3-methyl-1H-indole-2-carboxylic acid ethyl ester 
• 16381-47-8 5-chloro-3-methyl-1H-indole-2-carboxylic acid 
• 380448-07-7 5-chloro-3-formylindole-2-carboxylic acid 

Relevant articles and documents

Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities

Using a single drug to treat cancer with dual-targeting is an unusual approach when compared to other drug combinations. Dual-targeting agents were developed as a result of insufficient efficacy and drug resistance when single-targeting agents were used.

Design of C3-Alkenyl-Substituted 2-Indolylmethanols for Catalytic Asymmetric Interrupted Nazarov-Type Cyclization

The C3-alkenyl-substituted 2-indolylmethanols have been designed as a new class of substrates for catalytic asymmetric interrupted Nazarov-type cyclizations. In the presence of chiral phosphoric acid as a mild chiral Br?nsted acid, the interrupted Nazarov

Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT1 Selective Antagonists

The indole derivative, 3-((E)-3-((3-((E)-2-(7-chloroquinolin-2yl)vinyl)phenyl)amino)-3-oxoprop-1-en-1-yl)-7-methoxy-1H-indole-2-carboxylic acid (17k), was identified as a novel and highly potent and selective CysLT1 antagonist with IC50 values of 0.0059 ± 0.0011 and 15 ± 4 μM for CysLT1 and CysLT2, respectively.