43147-30-4Relevant academic research and scientific papers
Process for the production of 2-aryl-4-acyl-1.3.4-oxdiazolones-(5)
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, (2008/06/13)
A process for the production of 2-aryl-4-acyl-1.3.4-oxdiazolones-(5), in which an aromatic carboxylic acid hydrazide is reacted at a pH value of from 1.8 to 3.0 with phosgene in a mixture consisting of water and acetone at a temperature of from 0° C. to 50° C., subsequently the pH is increased to from 9.5 to 11.0, then about 100 mol % of a carboxylic acid chloride or about 50 mol % of a dicarboxylic acid chloride (based on mols of carboxylic acid hydrazide) is added and optionally from 10-4 to 1.0 mol % (based on mols of carboxylic acid hydrazide) of a tertiary amine or phosphine is added as a catalyst and the reaction is completed at a temperature from 0° C. to 50° C.
