1199-02-6

Basic information

• Product Name: 1,3,4-OXADIAZOL-2(3H)-ONE, 5-PHENYL-
• Synonyms: 1,3,4-OXADIAZOL-2(3H)-ONE, 5-PHENYL-;2-PHENYL-1,3,4-OXADIAZOL-2-IN-5-ONE
• CAS NO: 1199-02-6
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.14544
• Mol File: 1199-02-6.mol
• Article Data: 31

Chemical Properties

• Melting Point: 136～138℃
• Boiling Point: 242.1°Cat760mmHg
• Flash Point: 115.6°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 2.06E-05mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 1,3,4-OXADIAZOL-2(3H)-ONE, 5-PHENYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-OXADIAZOL-2(3H)-ONE, 5-PHENYL-(1199-02-6)
• EPA Substance Registry System: 1,3,4-OXADIAZOL-2(3H)-ONE, 5-PHENYL-(1199-02-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 1199-02-6(Hazardous Substances Data)

Usage

General Description

1,3,4-Oxadiazol-2(3H)-one, 5-phenyl- is a chemical compound with the molecular formula C9H6N2O2. It is an oxadiazole derivative with a phenyl group attached at the 5-position of the oxadiazole ring. 1,3,4-OXADIAZOL-2(3H)-ONE, 5-PHENYL- is known for its diverse array of biological activities, including anticancer, antimicrobial, and antiviral properties. It has also been studied for its potential use as a drug candidate for various medical conditions. The 1,3,4-oxadiazole scaffold is of particular interest in medicinal chemistry due to its unique structural features and promising pharmacological properties, making 1,3,4-oxadiazol-2(3H)-one, 5-phenyl- an important chemical compound for further research and development in the pharmaceutical industry.

InChI:InChI=1/C8H6N2O2/c11-8-10-9-7(12-8)6-4-2-1-3-5-6/h1-5H,(H,10,11)

Upstream product

• 89-24-7 5-phenylimidazolidine-2,4-dione 
• 7647-01-0 hydrogenchloride 
• 57064-92-3 3-benzoyl-5-phenyl-3H-[1,3,4]-oxadiazol-2-one 
• 27129-49-3 4-phenylimidazolidin-2-one 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 613-94-5 benzoic acid hydrazide 
• 2845-79-6 1-benzoyl semicarbazide 
• 29376-05-4 N-benzoyl-N'-chloro-urea 
• 614-22-2 1-benzoylurea 
• 92-52-4 biphenyl 
• 4231-62-3 1-benzoyl-1H-benzotriazole 
• 10465-97-1 N-benzoyl-N'-ethoxycarbonyl hydrazine 
• 1134-56-1 5-Phenyl-2-ethoxy-1,3,4-oxadiazole 
• 201230-82-2 carbon monoxide 

Downstream Products

• 57064-92-3 3-benzoyl-5-phenyl-3H-[1,3,4]-oxadiazol-2-one 
• 41763-04-6 5-phenyl-3-hydroxymethyl-1,3,4-oxadiazol-2(3H)-one 
• 41125-77-3 5-(4-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one 
• 117026-14-9 3-(2-dimethylamino-ethyl)-5-phenyl-3H-[1,3,4]oxadiazol-2-one; hydrochloride 
• 55084-83-8 2-phenyl-4-ethoxycarbonyl-1,3,4-oxadiazol-5(4H)-one 
• 199787-50-3 2-oxo-5-phenyl-[1,3,4]oxadiazole-3-carboxylic acid anilide 
• 861070-90-8 3-(4-nitro-benzoyl)-5-phenyl-3H-[1,3,4]oxadiazol-2-one 
• 115213-62-2 3-dimethylaminomethyl-5-phenyl-3H-[1,3,4]oxadiazol-2-one 
• 65975-47-5 4,4-diethyl-1-benzoyl semicarbazide 
• 603-54-3 N,N-diphenylurea 
• 613-94-5 benzoic acid hydrazide 
• 3658-33-1 benzoyl carbohydrazide 
• 41125-83-1 2-isopropoxy-5-phenyl-[1,3,4]oxadiazole 
• 41126-01-6 3-isopropyl-5-phenyl-1,3,4-oxadiazol-2(3H)-one 

Relevant articles and documents

Formation of oxadiazolones in the oxidative hydrolysis of alkylsulfanyl-1,3,4-oxadiazoles

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Investigation of Masked N-Acyl-N-isocyanates: Support for Oxadiazolones as Blocked N-Isocyanate Precursors

In contrast to carbon-substituted isocyanates that are common building blocks, N-substituted isocyanates remain underdeveloped and reports on their N-acyl derivatives (i. e. amido-isocyanates) are exceedingly rare. Herein, amido-isocyanates were investiga

Synthesis and In Vitro Anticancer Activity of Novel 1,3,4-Oxadiazole-Linked 1,2,3-Triazole/Isoxazole Hybrids

A series of new 1,3,4-oxadiazole-linked 1,2,3-triazole/isoxazole derivatives were designed and synthesized. All the synthesized compounds were screened for in vitro anticancer activity against four human cancer cells: HeLa (cervical), MDA-MB-231 (breast), DU-145 (prostate), and HEPG2 (liver). Among 17 compounds tested, 7a, 7c, and 7d showed potent activity toward four cell lines.