43170-60-1

Usage

Uses

Used in Organic Synthesis:
2-Pyrrolidinone, 1-(chloroacetyl)(9CI) is used as a building block in organic synthesis for the production of various chemicals and pharmaceuticals. Its unique structure and reactivity make it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Pyrrolidinone, 1-(chloroacetyl)(9CI) is used as an intermediate in the synthesis of various drugs. Its presence in the molecular structure of certain pharmaceuticals contributes to their therapeutic properties and efficacy.
Used in Agrochemical Production:
2-Pyrrolidinone, 1-(chloroacetyl)(9CI) is also utilized in the production of agrochemicals, where it serves as a key intermediate in the synthesis of various pesticides and other agricultural chemicals. Its role in these products helps to enhance crop protection and yield.
Used in Dyes and Pigments Industry:
In the dyes and pigments industry, 2-Pyrrolidinone, 1-(chloroacetyl)(9CI) is employed as an intermediate for the synthesis of various dyes and pigments. Its contribution to the color and stability of these products makes it an essential component in the formulation of various colorants.
Safety Precautions:
It is important to handle 2-Pyrrolidinone, 1-(chloroacetyl)(9CI) with care, as it is a potential irritant. Prolonged contact with skin and eyes may cause irritation. Proper safety measures, such as wearing protective clothing and using appropriate handling equipment, should be taken to minimize the risk of exposure.

InChI:InChI=1/C6H8ClNO2/c7-4-6(10)8-3-1-2-5(8)9/h1-4H2

Upstream product

• 616-45-5 2-pyrrolidinon 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1163791-46-5 C₂₈H₃₄N₆O₉ 
• 121365-04-6 1-[2-(Benzyl-methyl-amino)-acetyl]-pyrrolidin-2-one 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship studies of theophylline analogs on population responses in the rat hippocampus in vitro

We synthesized several theophylline analogs and tested the hypothesis that these compounds may be nootropic or cognitive enhancers by examining their effects on evoked population spikes recorded extracellularly in the CA1 region of the rat hippocampus. Whereas the length of the carbon chain on N7 had no effect, different size of the terminal lactam ring strongly influenced neuroactivity. Our results suggest that hexahydroazepin-2-one analogs have potential for further development as cognitive enhancers.

Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof

Novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular and neurovascular complications, including kidney disease, nerve damage, atherosclerosis, retinopathy, inflammatory disorders, immunological disorders, oxidative stress, dermatological disorders and discoloration of teeth, by breaking preformed AGE, of the general formula I, or pharmaceutically acceptable salts thereof, wherein, R1, R2, R3, X and m are as defined in the specification. Also disclosed is a method for preparation of the compounds of general formula (I) and pharmaceutical composition containing one or more compounds as defined above as active ingredients. Also disclosed is a method of treatment of a diabetic patient by administering the compounds as defined above, either singly or in combination with drugs for antidiabetic therapy.

Quaternary ammonium compounds as bleach activators and their preparation

Compounds of the formula I STR1 are claimed, as are their preparation and use, in which the radicals R1, R2 and R3 are organic substituents, L is either a lactam or a cyclic amidine and X is an appropriate anion. The novel compounds are employed as bleach activators in cleaners and detergents which have a bleaching action.

Rupture and Formation of a C-N Bond in a Stable Tetrahedral Intermediate

A complete description of the equilibrium and kinetic behaviour on the intramolecular rupture and formation of the C-N bond in the N-(2-aminoacetyl)-2-pyrrolidone (open form) in D2O has been made within the 1 -> the / ratios remain quite constant (1-2.5).Dynamic nmr(H) (line shape analysis) has been used to obtain the rate constants for the rupture and formation of the sTH.The ΔG* for the rupture from the zwitterionic structure of sTH is 9.4 kcal/mol and the associated barrier for the water assisted rupture from sTH-D* and sT species are 18.9 and 10.8 kcal/mol, respectively.Since the relative stabilities between the sTH and the open form are very similar (non identity thermoneutral reaction), the ΔG* values can be regarded as the intrinsic barrier for the cleavage of the C-N bond in tetrahedral intermediates.Therefore, these values can be used in the Marcus equation or the Valence bond configuration mixing.State correlation diagram formalism in order to evaluate the barriers associated with the rupture of tetrahedral intermediates in non-thermoneutral reactions.