43189-09-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(p-Hydroxyphenyl)glycine Ethyl Ester is used as a key intermediate for the synthesis of pharmaceuticals, particularly for the production of gabapentin, a medication used to treat various neurological conditions.
Used in Fragrance and Flavor Industry:
2-(p-Hydroxyphenyl)glycine Ethyl Ester is used as a building block in the creation of flavors and fragrances, capitalizing on its aromatic properties to enhance the sensory profiles of various products.
Used in Organic Synthesis:
2-(p-Hydroxyphenyl)glycine Ethyl Ester is utilized as a versatile component in organic synthesis, contributing to the development of a wide range of chemical compounds and materials.
Used in Antioxidant Supplements and Food Additives Industry:
2-(p-Hydroxyphenyl)glycine Ethyl Ester is used as an antioxidant agent in the production of health supplements and food additives, leveraging its antioxidant activity to provide potential health benefits and extend the shelf life of food products.

Upstream product

• 64-17-5 ethanol 
• 6324-01-2 p-hydroxyphenylglycine 
• 108-95-2 phenol 
• 70080-54-5 4-hydroxy-alpha-oxobenzeneacetic acid ethyl ester 

Downstream Products

• 77629-98-2 Diethyl 3-Azido-α--2-oxo-1-azetidinemalonate 
• 70875-48-8 Ethyl α--2-oxo-1-azetidineacetate 
• 71725-07-0 Diethyl α--2-oxo-1-azetidinemalonate 
• 70875-42-2 2--N-(3-bromopropionyl)glycine Ethyl Ester 
• 1473359-00-0 ethyl 2-[(5-[(2-amino-6-oxo-6,9-dihydro-1H-9-purinyl)methoxy]-2-oxo-1,3,2λ⁵-dioxaphosphinan-2-ylmethyl)amino] 2-(4-hydroxyphenyl)acetate 
• 70875-51-3 2-glycine Ethyl Ester Hydrotosylate 

Relevant academic research and scientific papers

Preparation method of amino-acid ester

The invention relates to a preparation method of amino-acid ester, and belongs to the field of synthesis of organic compounds. The preparation method of the amino-acid ester comprises the following steps: taking sulfur trioxide as a catalyst and a water-binding agent, catalyzing amino acid and alcohol to react so as to prepare sulfate of the amino-acid ester, then concentrating a reaction system to remove a reaction solvent and then adding water for dissolving, and neutralizing ammonia water to prepare the amino-acid ester. According to the technical scheme, the provided preparation method ofthe amino-acid ester has the advantages of mild reaction process, high yield, good purity, simplicity in operation and low cost. Concentrated condensate water of central mother liquor of the preparation method of the amino-acid ester can be directly subjected to biochemical treatment, solid by-products are high-purity ammonium sulfate, and can serve as chemical fertilizers, a reaction process is green and pollution-free, and thus, environmental protection is facilitated.

Method for preparing amino-acid ester

The invention relates to a method for preparing an amino-acid ester and belongs to the field of organic compound synthesis. The method comprises the following steps: by taking sulfur trioxide as a catalyst and a water bounding agent, catalyzing amino acid to react with an alcohol so as to prepare sulfate of the amino-acid ester, concentrating the reaction system, removing a reaction solvent, dissolving with water, and further neutralizing with ammonia water, thereby obtaining the amino-acid ester. The method for preparing the amino-acid ester, which is provided by the technical scheme of the invention, has the advantages of being gentle in reaction process, high in yield, high in purity, simple to operate and low in cost. By adopting the method for preparing the amino-acid ester, centrifugal mother liquid condensed water can be subjected to biochemical treatment directly, a solid byproduct of high-purity ammonium sulfate can be generated, the byproduct can be used as a chemical fertilizer, the reaction process is green and pollution-free, and the environment can be protected.

Inhibitors of lipoprotein(a) assembly

Compounds of the general structure A and B were investigated for their activity as lipoprotein(a), [Lp(a)], assembly (coupling) inhibitors. SAR around the amino acid derivatives (structure A) gave compound 14-6 as a potent coupling inhibitor. Oral dosing