432-88-2

Usage

Common uses

Reagent in organic synthesis
Solvent in various chemical reactions

Color

Colorless

State

Liquid

Odor

Faint

Solubility

Soluble in water and organic solvents

Flammability

Flammable

Safety precautions

Potential for skin, eye, and respiratory irritation
Store in a well-ventilated area
Keep away from sources of ignition

Industrial applications

Building block for drug synthesis in the pharmaceutical industry
Intermediate in the production of other chemicals

Upstream product

• 1093490-29-9 diethyl 1,1-difluoro-2-hydroxy-2-phenylpropylphosphonate 
• 113453-93-3 Difluormethyl-methyl-o-tolyl-carbinol 
• 98-86-2 acetophenone 
• 861721-54-2 1,1-difluoro-2-phenyl-1-(phenylsulfonyl)propan-2-ol 
• 1008-05-5 1-(3,3-difluoroprop-1-en-2-yl)-2-methylbenzene 
• 917-54-4 methyllithium 
• 431-05-0 1,1-difluoroacetone 
• 703-42-4 2,2-difluoro-1-(o-tolyl)ethan-1-one 
• 6699-93-0 (2-methylphenyl)lithium 

Downstream Products

• 345-60-8 α-(difluoromethyl)styrene 

Relevant academic research and scientific papers

Aromatic fluorocopolymers based on α-(difluoromethyl)styrene and styrene: Synthesis, characterization, and thermal and surface properties

A study on the α-(difluoromethyl)styrene (DFMST) reactivity under conventional radical copolymerization conditions is presented. Although the homopolymerization of DFMST failed, its radical bulk copolymerization with styrene (ST) led to the synthesis of f

α-(Difluoromethyl)styrene: Improved approach to grams scale synthesis

Improved, efficient, grams scale synthesis of α-(difluoromethyl)styrene (DFMST) based on nucleophilic difluoromethylation process using difluoromethylphenyl sulfone, is presented. Difluoromethylating agent (PhSO2CF2H) was obtained in two-step synthetic sequence with 69% overall yield. Three-step DFMST synthetic route was easily implemented for the preparation of gram quantities of the monomer, allowing for polymerization studies. The syntheses were based on the use of commercially available and reasonable in price starting materials and reagents.

Nucleophilic difluoromethylation and difluoromethylenation of aldehydes and ketones using diethyl difluoromethylphosphonate

New methodology for difluoromethylation and difluoromethylenation of aldehydes and ketones based on nucleophilic fluorination using diethyl difluoromethylphosphonate (1) was developed.

Facile preparation of difluoromethyl- and monofluoromethyl-containing amides via Ritter reaction

Both secondary and tertiary difluoromethylated carbinols were found to readily react with acetonitrile under the catalysis of concentrated sulfuric acid to give the corresponding difluoromethylated acetamides in good yields, which is remarkably more effic

Convenient synthesis of difluoromethyl alcohols from both enolizable and non-enolizable carbonyl compounds with difluoromethyl phenyl sulfone

A general and efficient nucleophilic difluoromethylation of carbonyl compounds (both enolizable and non-enolizable aldehydes and ketones) has been achieved by using a nucleophilic (phenylsulfonyl)difluoromethylation-reductive desul fonylation strategy. Di

Nucleophilic difluoromethylation of carbonyl compounds using TMSCF 2SO2Ph and Mg0-mediated desulfonylation

A new nucleophilic difluoromethylation chemistry using fluoride-induced (phenylsulfonyl)difluoromethylation with TMSCF2SO2Ph followed by the magnesium-metal-mediated desulfonylation has been achieved. This methodology is compatible w