43218-56-0 Usage
Chemical Properties
White Solid
Uses
A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects.
Biological Activity
ki: 2, 6.9, and 1.7 μm for α1a, α1b, α1d, respectivelymidodrine is the prodrug of the α1-adrenergic receptor agonist, 1-(2’,5’-dimethoxyphenyl)-2-aminoethanol.the α1-adrenergic receptor has some general functions similar with the α2-adrenergic receptor, but also has its own specific effects. α1-receptors primarily can mediate smooth muscle contraction and have other important functions as well.
in vitro
midodrine was identified as a prodrug forming an active metabolite, desglymidodrine, which is an α1-receptor agonist exerting its actions through activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature, leading to an increased vascular tone and elevation of blood pressure [1].
in vivo
a previous study was conducted to investigate the effect of intracerebroventricular injections of midodrine on the central nervous system of the rat. it was found that midodrine could decrease body temperature and increase locomotor activity, sedation in reserpinized rats as well as the cataleptic effect of haloperidol. midodrine could also enhance amphetamine-stimulated locomotor activity and reduce the amphetamine and apomorphine sterotypy [1].
references
[1] kleinrok z, jagieo-wójtowicz e, oktaba-polkowska a. central action of intraventricularly-injected midodrine in rats. arch int pharmacodyn ther. 1980 oct;247(2):217-33.[2] rai n, singh b, singh a, vijayvergiya r, sharma n, bhalla a, singh v. midodrine and tolvaptan in patients with cirrhosis and refractory or recurrent ascites: a randomised pilot study. liver int. 2017 mar;37(3):406-414.
Check Digit Verification of cas no
The CAS Registry Mumber 43218-56-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,2,1 and 8 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 43218-56:
(7*4)+(6*3)+(5*2)+(4*1)+(3*8)+(2*5)+(1*6)=100
100 % 10 = 0
So 43218-56-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H
43218-56-0Relevant articles and documents
COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS
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Page/Page column 45-49; 60, (2010/12/31)
The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.
AN IMPROVED PROCESS FOR THE SYNTHESIS OF (±) 2-AMINO-N-[2,(S,5-DIMETHOXYPHENYL)-2-HYDROXYETHYL] ACETAMIDE MONOHYDROCHLORIDE
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Page 11-12, (2008/06/13)
This invention relates to an improved process for synthesizing (±) 2-Amino-N-[2,(S,5-dimethoxyphenyl)-2-hydroxyethyl] acetamide monohydrochloride in good yield and in a cost effective manner from 1-(2,5dimethoxyphenyl)-2-bromoethanone by reacting the same
Process for the preparation of Midodrine
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, (2008/06/13)
The invention provides a process for the preparation of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide of the formula 1 by hydrogenolysis of substituted 2-dibenzylamino-N-[2-(2′,5′-dimethoxyphenyl)-2-hydroxy-ethyl]acetamide having the formula
