432531-71-0 Usage
Uses
Used in Pharmaceutical Industry:
(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylamide is used as a potential therapeutic agent for targeting programmed necrosis (necroptosis). (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation, which is a key signaling molecule in the necroptosis pathway. By inhibiting this pathway, the compound may offer a novel approach to treating conditions associated with uncontrolled cell death and inflammation.
Used in Chemical Research:
In the field of chemical research, (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylamide can be utilized as a starting material or intermediate for the synthesis of other complex organic molecules. Its unique structure and functional groups make it a valuable building block for the development of new compounds with diverse applications, such as in materials science, pharmaceuticals, and agrochemicals.
Used in Drug Design and Development:
(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide's ability to modulate the RIP3 signaling pathway makes it a promising candidate for drug design and development. Researchers can use (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide as a template to design new molecules with improved potency, selectivity, and pharmacokinetic properties. This could lead to the development of more effective therapies for a range of diseases, including those involving dysregulated cell death and inflammation.
Check Digit Verification of cas no
The CAS Registry Mumber 432531-71-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,2,5,3 and 1 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 432531-71:
(8*4)+(7*3)+(6*2)+(5*5)+(4*3)+(3*1)+(2*7)+(1*1)=120
120 % 10 = 0
So 432531-71-0 is a valid CAS Registry Number.
432531-71-0Relevant articles and documents
Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein
Liao, Daohong,Sun, Liming,Liu, Weilong,He, Sudan,Wang, Xiaodong,Lei, Xiaoguang
, p. 333 - 337 (2014/03/21)
Through high-throughput screening of 200000 compounds and subsequent structure-activity relationship (SAR) studies we identified necrosulfonamide (NSA) as a potent small molecule inhibitor for necroptosis, induced by a combination of TNF-a, Smac mimetic, and z-VAD-fmk (T/S/Z). Applying a forward chemical genetic approach, we utilized an NSA based chemical probe to further reveal that NSA selectively targeted the Mixed Lineage Kinase Domain-like Protein (MLKL) to block the necrosome formation.
