4330-99-8

Usage

Uses

Used in Pharmaceutical Industry:
Trimeprazine tartrate is used as an antipruritic agent for its pronounced antipruritic action, which may be unrelated to its histamine-antagonizing properties. It is particularly effective in treating itching and allergic reactions.
Used in Antimicrobial Applications:
Trimeprazine tartrate is used as an antibacterial and antimicrobial agent due to its ability to inhibit the growth of certain bacteria and microorganisms, making it useful in various medical and healthcare settings.
Used in Veterinary Medicine:
In the veterinary industry, Trimeprazine tartrate is used as an antihistamine and antipruritic agent for the treatment of itching and allergic reactions in animals, similar to its use in human medicine.

InChI:InChI=1/2C18H22N2S.C4H6O6/c2*1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20;5-1(3(7)8)2(6)4(9)10/h2*4-11,14H,12-13H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..0/s1

Synthetic route

cysteamine radical (40055-94-5) + trimeprazine semitartrate (4330-99-8) → 2C18H22N2S*C4H6O6*2H(1+) (1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1)

Conditions	Yield
In water Rate constant; pH 6.5, N2O;

2-hydroxy-ethylsulfanyl (68570-60-5) + trimeprazine semitartrate (4330-99-8) → 2C18H22N2S*C4H6O6*2H(1+) (1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1)

Conditions	Yield
In water Rate constant; pH 6.5, N2O;

2-carboxy-ethylsulfanyl (40055-90-1) + trimeprazine semitartrate (4330-99-8) → 2C18H22N2S*C4H6O6*2H(1+) (1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1)

Conditions	Yield
In water Rate constant; pH 6.5, N2O;

2-amino-2-carboxy-1,1-dimethyl-ethylsulfanyl (15784-30-2) + trimeprazine semitartrate (4330-99-8) → 2C18H22N2S*C4H6O6*2H(1+) (1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1)

Conditions	Yield
In water Rate constant; pH 6.5, N2O;

Cysteine thiyl radical (35772-84-0) + trimeprazine semitartrate (4330-99-8) → 2C18H22N2S*C4H6O6*2H(1+) (1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1)

Conditions	Yield
In water Rate constant; pH 6.5 (phosphate puffer), N2O;

glutathione thiyl radical (40055-99-0) + trimeprazine semitartrate (4330-99-8) → 2C18H22N2S*C4H6O6*2H(1+) (1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1)

Conditions	Yield
In water Rate constant; pH 6.5, N2O;

trimeprazine semitartrate (4330-99-8) + thiyl radical → 2C18H22N2S*C4H6O6*2H(1+) (1175-88-8, 2015-31-8, 4330-99-8, 14101-45-2, 21287-43-4, 39832-33-2, 66634-41-1)

Conditions	Yield
In water pH 6.5;

trimeprazine semitartrate (4330-99-8) → 3H-phenothiazin-3-one

Conditions	Yield
With β‐cyclodextrin In phosphate buffer for 1h; pH=6.8; Kinetics; Further Variations:; pH-values; Reagents; UV-irradiation;

Upstream product

• 40055-94-5 cysteamine radical 
• 4330-99-8 trimeprazine semitartrate 
• 68570-60-5 2-hydroxy-ethylsulfanyl 
• 40055-90-1 2-carboxy-ethylsulfanyl 
• 15784-30-2 2-amino-2-carboxy-1,1-dimethyl-ethylsulfanyl 
• 40055-99-0 glutathione thiyl radical 
• 35772-84-0 Cysteine thiyl radical 

Downstream Products

• 1175-88-8 2C₁₈H₂₂N₂S*C₄H₆O₆*2H⁽¹⁺⁾ 

Relevant academic research and scientific papers

Reactions of thiyl radicals with phenothiazines and other antioxidants in aqueous solutions. A pulse radiolysis study.

Reaction rate constants of thiyl radicals with phenothiazines, promethazine (PMZ), chlorpromazine (CPZ), prochlorperazine (PPZ), trimeperazine tarterate (TPZ), and other antioxidants, e. g., ascorbic acid and 2,2-azinobis(3-ethyl benzthiazoline-6 sulphonate) (ABTS) have been estimated using pulse radiolysis technique.In general they are quite high (108-109 M-1 s-1).The k value of cysteine, cysteamine, mercaptoethanol, and mercaptopropionic acid with similar structures and molecular weights are more or less similar for PMZ, CPZ, and PPZ.Rate constants are lower in value for PenS., DT.T, DT.E and GuS. radicals of phenothiazines showing that they are dependent upon the structure and the molecular weight of the compound. Rate constants are the same whether the thiyl radicals are generated from thiols or their corresponding disulphides.The k values for chlorine-containing phenothiazines, chlorpromazine, and prochlorperazine are higher than those of promothazine.