433212-64-7

Basic information

• Product Name: (2S)-methyl 2-[(5-acetyl-3-nitro-2-thienyl)amino]-3-phenylpropionate
• Synonyms: (2S)-methyl 2-[(5-acetyl-3-nitro-2-thienyl)amino]-3-phenylpropionate
• CAS NO: 433212-64-7
• Molecular Weight: 348.379
• Mol File: 433212-64-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-methyl 2-[(5-acetyl-3-nitro-2-thienyl)amino]-3-phenylpropionate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-methyl 2-[(5-acetyl-3-nitro-2-thienyl)amino]-3-phenylpropionate(433212-64-7)
• EPA Substance Registry System: (2S)-methyl 2-[(5-acetyl-3-nitro-2-thienyl)amino]-3-phenylpropionate(433212-64-7)

Safety Data

• Hazardous Substances Data: 433212-64-7(Hazardous Substances Data)

Upstream product

• 42456-75-7 5-acetyl-2-chloro-3-nitrothiophene 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 

Downstream Products

• 433212-80-7 (3S)-6-acetyl-3-benzyl-3,4-dihydrothieno[2,3-b]pyrazin-2(1H)-one 

Relevant articles and documents

Preparation of thieno[2,3-b]pyrazines as bioisosteres for quinoxaline derivatives with reverse transcriptase inhibition

Replacement of the fused aromatic moiety in GW-420867X, a HIV-1 specific nonnucleoside reverse transcriptase inhibitor, with thiophene provided 2-oxo-1,2,3,4-tetrahydrothieno[2,3-b]pyrazine derivatives. The synthesis starts with the reaction of 5-acyl-2-chloro-3-nitrothiophene and different amino acid derivatives. The resulting substitution products are reduced, cyclized and N-acylated to give the desired compounds (27-33).