433212-80-7

Basic information

• Product Name: Thieno[2,3-b]pyrazin-2(1H)-one, 6-acetyl-3,4-dihydro-3-(phenylmethyl)-, (3S)-
• CAS NO: 433212-80-7
• Molecular Formula: C15H14N2O2S
• Molecular Weight: 286.354
• Mol File: 433212-80-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Thieno[2,3-b]pyrazin-2(1H)-one, 6-acetyl-3,4-dihydro-3-(phenylmethyl)-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[2,3-b]pyrazin-2(1H)-one, 6-acetyl-3,4-dihydro-3-(phenylmethyl)-, (3S)-(433212-80-7)
• EPA Substance Registry System: Thieno[2,3-b]pyrazin-2(1H)-one, 6-acetyl-3,4-dihydro-3-(phenylmethyl)-, (3S)-(433212-80-7)

Safety Data

• Hazardous Substances Data: 433212-80-7(Hazardous Substances Data)

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 42456-75-7 5-acetyl-2-chloro-3-nitrothiophene 
• 433212-64-7 (2S)-methyl 2-[(5-acetyl-3-nitro-2-thienyl)amino]-3-phenylpropionate 

Relevant articles and documents

Preparation of thieno[2,3-b]pyrazines as bioisosteres for quinoxaline derivatives with reverse transcriptase inhibition

Replacement of the fused aromatic moiety in GW-420867X, a HIV-1 specific nonnucleoside reverse transcriptase inhibitor, with thiophene provided 2-oxo-1,2,3,4-tetrahydrothieno[2,3-b]pyrazine derivatives. The synthesis starts with the reaction of 5-acyl-2-chloro-3-nitrothiophene and different amino acid derivatives. The resulting substitution products are reduced, cyclized and N-acylated to give the desired compounds (27-33).