433228-88-7

Basic information

• Product Name: Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI)
• Synonyms: Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI);(R)-1-(3,5-Difluorophenyl)ethanol
• CAS NO: 433228-88-7
• Molecular Formula: C8H8F2O
• Molecular Weight: 158.1453264
• Product Categories: HALIDE
• Mol File: 433228-88-7.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI)(433228-88-7)
• EPA Substance Registry System: Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI)(433228-88-7)

Safety Data

• Hazardous Substances Data: 433228-88-7(Hazardous Substances Data)

Usage

General Description

Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI) is a chemical compound with a molecular formula C8H8F2O. Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI) is also known as 3,5-difluoro-alpha-methylbenzyl alcohol and is primarily used as a building block in the synthesis of various pharmaceutical and agrochemical products. It is a white solid at room temperature and is soluble in organic solvents. Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaR)- (9CI) has asymmetric carbon and exists in the alphaR form. It is important to handle this chemical with caution as it may pose health risks if not handled properly.

Upstream product

• 117358-52-8 1-ethyl-3,5-difluorobenzene 
• 123577-99-1 3′,5′-difluoroacetophenone 
• 32085-88-4 3,5-difluorobenzaldehyde 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 321318-29-0 (R)-1-(3,5-difluorophenyl)ethan-1-amine 
• 1620014-24-5 N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide 
• 1620014-27-8 4-[(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-(trifluoromethyl)piperidin-1-yl]-3-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 
• 1620013-79-7 N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide 
• 1620013-80-0 tert-butyl ((3R,4R,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-2,3-dihydrofuro[2,3-b]pyridin-4-yl}-5-methylpiperidin-3-yl)carbamate 
• 1355011-40-3 6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxylic acid 
• 1355011-39-0 methyl 6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxylate 
• 1063733-77-6 2-(3,5-difluorophenoxy)propan-2-ol 
• 123577-99-1 3′,5′-difluoroacetophenone 
• 1620013-87-7 N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide 
• 1620013-89-9 tert-butyl ((3S,5R)-1-{3-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl}-5-methylpiperidin-3-yl)carbamate 
• 1620013-88-8 4-{(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-methylpiperidin-1-yl}-3-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 
• 1586045-19-3 1-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol 
• 1586040-47-2 N-(5-((2S,5R,6R)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-6-(2,6-difluoro-4-(1-hydroxyethyl)phenyl)-5-fluoropicolinamide 

Relevant articles and documents

Chromoselective Photocatalysis Enables Stereocomplementary Biocatalytic Pathways**

Controlling the selectivity of a chemical reaction with external stimuli is common in thermal processes, but rare in visible-light photocatalysis. Here we show that the redox potential of a carbon nitride photocatalyst (CN-OA-m) can be tuned by changing the irradiation wavelength to generate electron holes with different oxidation potentials. This tuning was the key to realizing photo-chemo-enzymatic cascades that give either the (S)- or the (R)-enantiomer of phenylethanol. In combination with an unspecific peroxygenase from Agrocybe aegerita, green light irradiation of CN-OA-m led to the enantioselective hydroxylation of ethylbenzene to (R)-1-phenylethanol (99 % ee). In contrast, blue light irradiation triggered the photocatalytic oxidation of ethylbenzene to acetophenone, which in turn was enantioselectively reduced with an alcohol dehydrogenase from Rhodococcus ruber to form (S)-1-phenylethanol (93 % ee).

Enantioselective Bioamination of Aromatic Alkanes Using Ammonia: A Multienzymatic Cascade Approach

Chiral amines are common drug building blocks and important active pharmaceutical ingredients. Preparing these functionalized compounds from simple materials, such as alkanes, is of great interest. We recently developed an artificial bioamination cascade for the C?H amination of cyclic alkanes by combining P450 monooxygenase, alcohol dehydrogenase, and amine dehydrogenase. Herein, this system has been extended to the synthesis of chiral aromatic amines. In the first hydroxylation step, process optimization increased the conversion to 77 %. Two stereoselectively complementary alcohol dehydrogenases and an amine dehydrogenase were selected for the bioconversion of aromatic hydrocarbons to amines. The amination reaction was optimized with respect to cofactor addition and enzyme dosage. Isopropanol was added to decrease ketone intermediate accumulation in the amination step, which further enhanced the overall conversion. This cascade system converted a panel of hydrocarbon substrates into the corresponding amines with excellent optical purity (>99 % ee) and moderate conversion ratios (13–53 %).

FUNGICIDAL COMPOSITIONS

The present invention provides a composition comprising a combination of components A) and B), wherein component A) is a compound of formula (I) and the component (B) is a further fungicide, insecticide or herbicide.