433330-81-5

Basic information

• Product Name: 4,5-dihydro-5-phenyl-6-(4-chlorophenyl)-3-(2H)-pyridazinone
• Synonyms: 4,5-dihydro-5-phenyl-6-(4-chlorophenyl)-3-(2H)-pyridazinone
• CAS NO: 433330-81-5
• Molecular Weight: 284.745
• Mol File: 433330-81-5.mol

Chemical Properties

• CAS DataBase Reference: 4,5-dihydro-5-phenyl-6-(4-chlorophenyl)-3-(2H)-pyridazinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dihydro-5-phenyl-6-(4-chlorophenyl)-3-(2H)-pyridazinone(433330-81-5)
• EPA Substance Registry System: 4,5-dihydro-5-phenyl-6-(4-chlorophenyl)-3-(2H)-pyridazinone(433330-81-5)

Safety Data

• Hazardous Substances Data: 433330-81-5(Hazardous Substances Data)

Upstream product

• 101272-92-8 β-p-Chlorbenzoyl-β-phenyl-propionsaeure 
• 103-82-2 phenylacetic acid 
• 59086-23-6 3-Phenyl-3-(4-chlor-benzoyl)-propionsaeure-aethylester 
• 103-80-0 phenylacetyl chloride 
• 1889-71-0 4'-chloro-2-phenylacetophenone 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 1193086-76-8 C₁₆H₁₅ClN₂ 
• 136549-56-9 6-chloro-3-(4-chloro-phenyl)-4-phenyl-pyridazine 
• 433330-83-7 6-(4-chloro-phenyl)-5-phenyl-2H-pyridazin-3-one 

Relevant articles and documents

One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy

To access useful heterocycles in medicinal chemistry such as pyridazinones, dihydropyrimidinones, and dihydropyrimidinthiones, a "green" mild and highly efficient one-pot triple cascade was developed involving a Claisen-decarboxylation, electrophilic reaction, and subsequent heterocyclization. In addition, indazoles and benzofurans could also be constructed via a double cascade. To develop the cascade process, a direct Claisen-decarboxylation reaction was firstly optimized. This reaction can then couple with electrophilic reactions including alkylation, Michael addition or aldol reaction to enable the preparation of various aryl ketones in a one-pot fashion. The Royal Society of Chemistry 2012.

Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists

The synthesis and structure-activity relationship studies of 1,4,5,6-tetrahydropyridazines are described. The target compounds 3-5 represent a novel class of potent and selective CB1 receptor antagonists.

Mono- and di-substituted 5,6-diphenyl-3-alkylaminopyridazines active as ACAT inhibitors

A series of mono- or di-para-substituted 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. The compound which combines a chlorine atom on the 6-phenyl ring and a n-hexylamino chain showed a significant enhancement of activity with respect to the unsubstituted derivative. Attempts to correlate the activity of the compounds to their structural features, also through theoretical calculations, are reported.