59086-23-6

Basic information

• Product Name: 3-Phenyl-3-(4-chlor-benzoyl)-propionsaeure-aethylester
• Synonyms: 3-Phenyl-3-(4-chlor-benzoyl)-propionsaeure-aethylester
• CAS NO: 59086-23-6
• Molecular Weight: 316.784
• Mol File: 59086-23-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Phenyl-3-(4-chlor-benzoyl)-propionsaeure-aethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenyl-3-(4-chlor-benzoyl)-propionsaeure-aethylester(59086-23-6)
• EPA Substance Registry System: 3-Phenyl-3-(4-chlor-benzoyl)-propionsaeure-aethylester(59086-23-6)

Safety Data

• Hazardous Substances Data: 59086-23-6(Hazardous Substances Data)

Upstream product

• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 105-36-2 ethyl bromoacetate 
• 1889-71-0 4'-chloro-2-phenylacetophenone 

Downstream Products

• 433330-83-7 6-(4-chloro-phenyl)-5-phenyl-2H-pyridazin-3-one 
• 433330-81-5 4,5-dihydro-5-phenyl-6-(4-chlorophenyl)-3-(2H)-pyridazinone 
• 136549-56-9 6-chloro-3-(4-chloro-phenyl)-4-phenyl-pyridazine 
• 101272-92-8 β-p-Chlorbenzoyl-β-phenyl-propionsaeure 

Relevant articles and documents

Mono- and di-substituted 5,6-diphenyl-3-alkylaminopyridazines active as ACAT inhibitors

A series of mono- or di-para-substituted 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. The compound which combines a chlorine atom on the 6-phenyl ring and a n-hexylamino chain showed a significant enhancement of activity with respect to the unsubstituted derivative. Attempts to correlate the activity of the compounds to their structural features, also through theoretical calculations, are reported.