4336-19-0

Basic information

• Product Name: 1-Cyclohexene-1,2-dicarboxylic acid dimethyl ester
• Synonyms: 1-Cyclohexene-1,2-dicarboxylic acid dimethyl ester
• CAS NO: 4336-19-0
• Molecular Formula: C₁₀H₁₄O₄
• Molecular Weight: 198.24
• Mol File: 4336-19-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 310°C (estimate)
• Flash Point: 124.4°C
• Appearance: /
• Density: 1.0143 (rough estimate)
• Vapor Pressure: 0.0108mmHg at 25°C
• Refractive Index: 1.4720 (estimate)
• CAS DataBase Reference: 1-Cyclohexene-1,2-dicarboxylic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclohexene-1,2-dicarboxylic acid dimethyl ester(4336-19-0)
• EPA Substance Registry System: 1-Cyclohexene-1,2-dicarboxylic acid dimethyl ester(4336-19-0)

Safety Data

• Hazardous Substances Data: 4336-19-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 14, p. 1193, 1984 DOI: 10.1080/00397918408076799

InChI:InChI=1/C10H14O4/c1-13-9(11)7-5-3-4-6-8(7)10(12)14-2/h3-6H2,1-2H3

Upstream product

• 140459-96-7 (1R,2R)-1,2-cyclohexanedicarboxylic acid dimethyl ester 
• 46022-05-3 (1R,2R)-(-)-trans-cyclohexane-1,2-dicarboxylic acid 
• 1292320-69-4 (1R,2R)-2-(nitromethyl)cyclohexane-1-carboxylic acid 
• 186581-53-3 diazomethane 
• 2426-02-0 3,4,5,6-Tetrahydrophthalic anhydride 
• 505-48-6 octane-1,8-dioic acid 
• 624-49-7 dimethylfumarate 
• 84565-17-3 C₁₁H₁₂O₄^(2-)*2Li⁽¹⁺⁾ 
• 3014-58-2 dimethyl (exo,endo)-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate 
• 74-88-4 methyl iodide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 14309-54-7 dimethyl cyclohexa-1,4-diene-1,2-dicarboxylate 
• 4336-20-3 dimethyl 1,2-cyclohexanedicarboxylate 
• 868-74-6 2,7-dibromooctanedioic acid dimethyl ester 

Downstream Products

• 149141-02-6 3-bromo-1-cyclohexene-1,2-dicarboxylic acid dimethylester 
• 3999-69-7 1,2-bis-1-cyclohexene 
• 75676-78-7 1,2-bis-1-cyclohexene diformate 

Relevant articles and documents

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Synthetic studies on CP-225,917 and CP-263,114: Access to advanced tetracyclic systems by intramolecular conjugate displacement and [2,3]-wittig rearrangement

An advanced intermediate related to the structures of CP-225,917 and CP-263,114 was constructed by a sequence based on the use of Grob-like fragmentation, intramolecular conjugate displacement, and [2,3]-Wittig rearrangement. A variant of the [2,3]-Wittig rearrangement was developed.

Bis-esters from maleic anhydrides under neutral conditions: Protection of the anhydride of the natural product cornexistin

Trimethylsilyldiazomethane converts maleic anhydride derivatives in alcoholic THF to bis-esters. The highly acid and base sensitive natural product cornexistin was converted to its bis-methyl ester in 70-75% yield and to the mixed benzyl/methyl ester in 61% yield. The mixed ester can be converted back to cornexistin via transfer hydrogenation.