140459-96-7

Usage

Uses

Used in Chemical Synthesis:
(1R.2R)-DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE is used as a chemical reagent for the synthesis of advanced tetracyclic systems. Its unique structure and reactivity allow for the creation of complex molecular architectures that are essential in the development of new pharmaceuticals, materials, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (1R.2R)-DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE is used as a key intermediate in the synthesis of various drug candidates. Its ability to form complex tetracyclic systems makes it a valuable component in the development of novel therapeutic agents with improved efficacy and selectivity.
Used in Material Science:
(1R.2R)-DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE is also utilized in the field of material science for the development of advanced polymers and other materials with unique properties. Its incorporation into these materials can lead to enhanced performance characteristics, such as increased strength, durability, or chemical resistance.

Upstream product

• 186581-53-3 diazomethane 
• 46022-05-3 (1R,2R)-(-)-trans-cyclohexane-1,2-dicarboxylic acid 
• 131-11-3 phthalic acid dimethyl ester 
• 67-56-1 methanol 
• 2305-32-0 trans-1,2-cyclohexanedicarboxylic acid 
• 31139-02-3 (1R,6S)-6-methoxycarbonyl-3-cyclohexene-1-carboxylic acid 
• 4841-84-3 dimethyl cis-1,2,3,6-tetrahydrophthalate 
• 150024-72-9 dimethyl (R,R)-(-)-trans-1,2-cyclohex-4-ene-1,2-dicarboxylate 
• 1292320-69-4 (1R,2R)-2-(nitromethyl)cyclohexane-1-carboxylic acid 

Downstream Products

• 65376-05-8 (+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane 
• 186204-35-3 (1R,2R)-(-)-trans-cyclohexane-1,2-diylbis(methylene)dimethanesulfonate 
• 41902-36-7 1,2-dimethyl cyclohex-2-ene-1,2-dicarboxylate 
• 4336-19-0 1,2-dimethyl cyclohex-1-ene-1,2-dicarboxylate 
• 167819-32-1 (1R,2R)-α,α,α',α'-tetraphenylcyclohexane-1,2-dimethanol 
• 367514-88-3 (3aR,4S,7R,7aS)-2-[((1R,2R)-2-{[4-(l1,2-benzisothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl)methyl]hexahydro-1H-4,7-methanisoindol-1,3-dione hydrochloride 
• 194861-74-0 lurasidone 

Relevant academic research and scientific papers

The Construction of Homochiral Lanthanide Quadruple-Stranded Helicates with Multiresponsive Sensing Properties toward Fluoride Anions

A series of unique homochiral lanthanide tetranuclear quadruple-stranded helicates have been self-assembled controllably by using the intrinsic advantages of chiral bridging ligands, (S)-H2L and (R)-H2L, and lanthanide ions with high coordination numbers. The self-assembly process of these chiral helicates not only ensures the structural stability and quadruple-stranded feature of lanthanide cluster in the solid state and solution, but also achieves effective transfer and amplification of the chirality code from the ligand to a higher supramolecular level. Moreover, through using optical rotation, circular dichroism spectra analysis, and luminescence measurements, we demonstrate that these chiral lanthanide helicates could serve as sensitive and multi-responsive sensors to recognize and detect F? anions based on the change of chiral signal and NIR luminescence simultaneously, which represents a meaningful exploration for developing functional lanthanide-based polynuclear clusters.

Ultralow-Molecular-Weight Stimuli-Responsive and Multifunctional Supramolecular Gels Based on Monomers and Trimers of Hydrazides

The simpler, the better. A series of simple, neutral and ultralow-molecular-weight (MW: 140–200) hydrazide-derived supramolecular gelators have been designed and synthesized in two straightforward steps. For non-conjugated cyclohexane-derived hydrazides, their monomers can self-assemble to form gels through intermolecular hydrogen bonds and dipole-dipole interactions. Significantly, conjugated phthalhydrazide can self-aggregate into planar and circular trimers through intermolecular hydrogen bonds and then self-assemble to form gels through intermolecular π–π stacking interactions. It is interesting that these simple gelators exhibit unusual properties, such as self-healing, multi-response fluorescence, and visual and selective recognition of chiral (R)/(S)-1,1′-binaphthalene-2,2′-diamine and S2? through much different times of gel re-formation and blue-green color change, respectively. These results underline the importance of supramolecular gels and extend the scope of supramolecular gelators.

Synthesis of phthalate-free plasticizers by hydrogenation in water using RhNi bimetallic catalyst on aluminated SBA-15

In this study, rhodium-nickel bimetallic nanoparticles loaded on aluminated silica (RhNi/Al-SBA-15) were used as catalysts for the hydrogenation of phthalate in water to produce environmentally acceptable non-phthalate plasticizers. Chemical fluid deposition (CFD) was used to dope metals onto the aluminated silica support, which helped to create a uniform structure of RhNi on Al-SBA-15. The introduction of Ni helped to reduce the use of expensive Rh and increase the number of metal active sites by reducing the bimetallic nanoparticle size. Aluminated SBA-15 not only acted as the support for the RhNi bimetallic catalyst but also enhanced the reaction efficiency by introducing Br?nsted and Lewis acid sites and the absorption of phthalates on the catalyst in water. The physicochemical properties of prepared catalysts were characterized by N2 adsorption-desorption isotherm, X-ray diffraction (XRD), in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), Scanning electron microscopy (SEM), and Transmission electron microscopy (TEM). The catalytic performance of the synthesized catalysts was evaluated with the hydrogenation of dimethyl phthalate (DMP). Despite the low solubility of DMP in water, the hydrogenation using Rh0.5Ni1.5/Al-SBA-15 was carried out with an 84.4% reaction yield (cis-?:?trans- = 97.5?:?2.5) at 80 °C using 1000 psi of H2 after 2 h.

Based on the chiral diamine spiro skeleton chiral phosphorus nitrile catalyst, preparation method and application thereof

The invention provides a chiral phosphazene catalyst based on a spiro framework adopting chiral diamine, a preparation method and an application of the chiral phosphazene catalyst. The catalyst has a structure represented in the general formula: (RX-)3P=NR', chiral groups are introduced through R and R', and the catalyst has a structure with two seven-membered rings in centered connection through phosphorspirol. Optically pure tartaric acid or substituted hexahydrophthalic acid or 1,2-cyclopentanedicarboxylicacid,(1R,2S)-rel- is taken as a raw material, chiral diamine is generated through esterification, a Grignard reaction, an optional chlorination reaction, an azido reaction and a reduction reaction of the raw material, then chiral diamine and phosphorus pentachloride have a spirocyclization reaction to construct a phosphorspirol-centered screw ring, the chiral phosphazene molecular catalyst is obtained under the alkaline condition, and a method for substituting azido for hydroxyl directly has good application and popularization value. The catalyst has the advantages of high catalysis efficiency, good stereoselectivity, mild conditions, economy, environmental protection, simplicity and convenience in operation and the like as well as popularization and application prospects.

Chiral organic ligand and preparation method and application of near-infrared rare-earth complex of chiral organic ligand

The invention discloses a chiral organic ligand and a preparation method and application of a near-infrared rare-earth complex of the chiral organic ligand. The organic ligand has the characteristics of a multidentate ligand and bridging metal ions and can be combined with rare-earth ions to form a multi-core structure. The rare-earth complex synthesized by the chiral ligand is a four-core and four-spiral complex with single chirality and a stable structure. The rare-earth spiral complex has a chiral characteristic and a near-infrared luminescence characteristic at the same time. By using formation of a hydrogen bond of NH and fluorinion on the ligand in the complex, simultaneous change of a chiral signal and a near-infrared luminescence signal can be affected, and multi-mode selective detection of the fluorinion is achieved.

Chiral acylhydrazone compound and preparation method and application of rare earth complex

The invention discloses a chiral acylhydrazone compound and a preparation method and an application of rare earth complex. The ligands of the complex contain acylhydrazone perssad with polydentate ligand characteristics and can be bond with rare earth ions to obtain a singular chirality, constitutionally stable quad-core quad-screw complex; the formation is by utilizing the NH on the ligands and the hydrogen bond of fluorion in the complexes, and thereby the selective identification and detection of optical rotation of fluorion by optical rotation signals of the chiral complexes are achieved.

Preparation method for lurasidone hydrochloride

The invention discloses a preparation method for lurasidone hydrochloride. According to the preparation method, trans-1,2-cyclohexanedicarboxylic acid (SM-1) is used as a raw material and subjected to resolution, methyl esterification, reduction, methylsulfonylation, condensation, recrystallization and salt formation so as to eventually obtain lurasidone hydrochloride. The preparation method provided by the invention greatly reduces production cost and has the characteristics of high product yield, easy operation, low toxicity and suitability for industrial large-scale production.

PROCESS FOR THE PREPARATION OF LURASIDONE HYDROCHLORIDE

Provided herein is a process for the preparation of the antipsychotic agent lurasidone hydrochloride useful for the treatment of schizophrenia.

Synthetic studies on CP-225,917 and CP-263,114: Access to advanced tetracyclic systems by intramolecular conjugate displacement and [2,3]-wittig rearrangement

An advanced intermediate related to the structures of CP-225,917 and CP-263,114 was constructed by a sequence based on the use of Grob-like fragmentation, intramolecular conjugate displacement, and [2,3]-Wittig rearrangement. A variant of the [2,3]-Wittig rearrangement was developed.

PROCESS FOR THE PREPARATION OF AN ANTIPSYCHOTIC AGENT

The present invention provides a process for the preparation of an antipsychotic agent useful for the treatment of schizophrenia.