4337-43-3

Usage

Uses

Used in Organic Synthesis:
5-Chloro-1,2-benzisothiazol-3(2H)-one is used as a synthetic intermediate for the production of various organic compounds. Its unique chemical structure allows it to participate in a range of reactions, such as substitution, addition, and condensation, leading to the formation of a wide array of products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Chloro-1,2-benzisothiazol-3(2H)-one is used as a building block for the development of new drugs. Its chemical properties make it a versatile component in the synthesis of various drug candidates, particularly those with potential therapeutic applications.
Used in Chemical Research:
5-Chloro-1,2-benzisothiazol-3(2H)-one is also employed in chemical research as a model compound for studying the properties and reactivity of benzisothiazolone derivatives. This helps researchers gain a deeper understanding of the structure-activity relationships and the potential applications of these compounds in various fields.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 5-Chloro-1,2-benzisothiazol-3(2H)-one is used as a key intermediate for the synthesis of various dyes and pigments. Its chemical properties contribute to the development of colorants with specific characteristics, such as color intensity, stability, and resistance to various environmental factors.
Used in Agrochemical Industry:
5-Chloro-1,2-benzisothiazol-3(2H)-one is also utilized in the agrochemical industry for the synthesis of various agrochemical products, such as pesticides and herbicides. Its unique chemical structure allows for the development of compounds with targeted biological activity, contributing to the control of pests and weeds in agriculture.

InChI:InChI=1/C7H4ClNOS/c8-4-1-2-6-5(3-4)7(10)9-11-6/h1-3H,(H,9,10)

Upstream product

• 147-93-3 Thiosalicylic acid 
• 19993-66-9 4,4'-dichloro-2,2'-disulfanediyl-bis-benzoyl chloride 
• 52948-10-4 5-chloro-2-mercapto-benzoic acid methyl ester 
• 934180-39-9 2-benzylsulphanyl-5-chloro-benzamide 
• 131002-02-3 2-bromo-5-chlorobenzamide 
• 19993-65-8 4,4'-dichloro-2,2'-disulfanediyl-di-benzoic acid 
• 256947-58-7 methyl 5-chloro-2-sulfenamoylbenzoate 
• 56-23-5 tetrachloromethane 
• 7782-50-5 chlorine 
• 7705-08-0 iron(III) chloride 

Relevant academic research and scientific papers

An efficient approach to construct benzisothiazol-3(2: H)-ones via copper-catalyzed consecutive reaction of 2-halobenzamides and carbon disulfide

An efficient copper-catalyzed reaction for the synthesis of benzisothiazol-3(2H)-ones has been developed, starting from easily available 2-halobenzamides and carbon disulfide, which gave the corresponding target products in 30-89% yield for 25 examples. The reaction proceeds via a consecutive process with S-C bond and S-N bond formation.

9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS

The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula (I), wherein R1 is H or C1-5alkyl; X is O or NR2, wherein R2 is H, C1-5alkyl or C2-5acyl and Ar is C6-10aryl or a 5-10 membered heteroaryl ring system, both being optionally substituted with one to three of R3-R5 independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynyl, CN, NO2, hydroxy, phenyl, phenoxy and phenylC1-2alkoxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein said phenyl, phenoxy and phenylC1-2alkoxy are optionally substituted with one to three substituents independently selected from halogen and methyl or two of R3-R5 at adjacent positions together form a methylenedioxy or propylene unit, with the proviso that the compounds exo-9-methyl-3-phenoxy-9-azabicyclo[3.3.1]nonane and N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H indazole-5-amine are excluded, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.

9-Azabicyclo[3.3.1]nonane derivatives

The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.

A facile synthesis of 1,2-benzisothiazolin-3-ones from thiosalicylates

Synthesis of 1,2-benzisothiazolin-3-ones by cyclization of 2- sulfenamoylbenzoates, which were prepared from amination of thiosalicylates by hydroxylamine-O-sulfonic acid, was examined. Although treatment of methyl 2-sulfenamoylbenzoate on heating gave unexpected 2-(2- methoxycarbonylphenylthio)-1,2-benzisothiazolin-3-one, the treatment with base at room temperature afforded 1,2-benzisothiazolin-3-one in a good yield.