433711-87-6

Upstream product

• 623-47-2 propynoic acid ethyl ester 
• 433711-86-5 C₂₂H₃₆N₂O₆ 
• 176108-62-6 (R)-4-but-3-enoyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester 
• 335693-75-9 (1S,2S)-(1-formyl-2-methoxy-2-methylpentyl)-carbamic acid tert-butyl ester 
• 335693-71-5 ((1R,2S)-1-Hydroxymethyl-2-methoxy-2-methyl-pentyl)-carbamic acid tert-butyl ester 
• 433711-93-4 (R)-4-((S)-1-Methoxy-1-methyl-butyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 433711-79-6 (4R,1'S)-4-(1-hydroxy-1-methyl-butyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester 
• 167102-62-7 (R)-N,O-isopropylidenyl-2-(N-tert-butyloxycarbonylamino)-3-oxo-propanamide-N,O-dimethyl-hydroxyamine 

Downstream Products

• 335679-69-1 A-315675 
• 433711-91-2 (4S,5R)-5-((1R,2S)-1-Amino-2-methoxy-2-methyl-pentyl)-1-(2,4-dimethoxy-benzyl)-4-((Z)-propenyl)-pyrrolidin-2-one 
• 433711-88-7 {(2S)-methoxy-(1R)-[1'-(2,4-dimethoxybenzyl)-5'-oxo-2',5'-dihydro-1H-pyrrol-(2'R)-yl]-(2S)-methylpentyl}-carbamic acid tert-butyl ester 
• 433711-92-3 N-{(2S)-methoxy-(1R)-[1-(2,4-dimethoxybenzyl)-5-oxo-(3S)-Z-propenylpyrrolidin-(2R)-yl]-(2S)-methylpentyl}-acetamide 
• 433711-89-8 {(2S)-methoxy-(1R)-[1-(2,4-dimethoxy)-benzyl-5-oxo-(3S)-Z-propenylpyrrolidin-(2R)-yl]-(2S)-methylpentyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Total synthesis of A-315675: A potent inhibitor of influenza neuraminidase

A concise, stereocontrolled, and practical synthesis of a neuraminidase inhibitor consisting of a highly functionalized D-proline scaffold is described. Key features involve a stereocontrolled addition of a propiolate ester to a chiral nonracemic nitrone