435273-55-5

Usage

Uses

Used in Pharmaceutical Research and Development:
4-Bromo-2-methylisoindolin-1-one is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of new drugs with potential therapeutic applications, contributing to the advancement of medicine.
Used in Organic Synthesis:
In the field of organic chemistry, 4-Bromo-2-methylisoindolin-1-one serves as a building block for the construction of more complex organic molecules. Its reactivity and structural features make it a versatile component in the synthesis of a wide range of chemical products, from specialty chemicals to advanced materials.

InChI:InChI=1/C9H8BrNO/c1-11-5-7-6(9(11)12)3-2-4-8(7)10/h2-4H,5H2,1H3

Upstream product

• 593-51-1 methylamine hydrochloride 
• 337536-14-8 methyl 3-bromo-2-(bromomethyl)benzoate 
• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 99548-54-6 methyl 3-bromo-2-methylbenzoate 
• 74-89-5 methylamine 

Downstream Products

• 1042722-39-3 2-(2-methyl-1-oxoisoindolin-4-yl)benzaldehyde 
• 1257996-66-9 4-bromo-2-methyl-7-nitro-2,3-dihydro-isoindol-1-one 
• 1380302-86-2 sodium ethyl (4-{[4-({7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate 
• 1257996-05-6 diethyl (4-{[4-({7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate 

Relevant academic research and scientific papers

CARBOLINE DERIVATIVE SERVING AS BROMODOMAIN INHIBITOR

Disclosed in the present invention is a carboline derivative serving as an bromodomain inhibitor. The carboline derivative in the present invention can be used as an bromodomain inhibitor, and can provide a method and a pharmaceutical composition for controlling diseases intervened by a bromodomain protein.

MACROCYCLIC KINASE INHIBITORS

Compounds of Formula (I): wherein variables are defined herein, and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers for which FAK inhibition is beneficial.

PHENANTHRENE LACTAM DERIVATIVES HAVING ANTICANCER ACTIVITY AND METHOD FOR THE PREPARATION THEREOF

The present invention relates to a phenanthrene lactam derivative having anticanter activity, a method for the preparation thereof, and a pharmaceutical composition comprising same.

Synthesis of aristolactam analogues and evaluation of their antitumor activity

A series of natural aristolactams and their analogues have been prepared and evaluated for antitumor activity against human cancer cells, including multi-drug resistant cell lines. Naturally occurring aristolactams, such as aristolactam BII (cepharanone B

Isoindolinone kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS

Compounds having the formula, (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds and compositions containing the compounds.