435273-55-5

Basic information

• Product Name: 4-BROMO-2-METHYLISOINDOLIN-1-ONE
• Synonyms: 4-BROMO-2-METHYLISOINDOLIN-1-ONE;1H-Isoindol-1-one,4-bromo-2,3-dihydro-2-methyl-;4-Bromo-2,3-dihydro-2-methyl-1H-isoindol-1-one, 4-Bromo-2,3-dihydro-2-methyl-1-oxo-1H-isoindole;4-broMo-2-Methyl-2,3-dihydro-1H-isoindol-1-one;4-(1-Methoxypropan-2-yloxy)aniline;4-Bromo-2-methyl-2,3-dihydro-isoindol-1-one;4-bromo-2-methyl-3H-isoindol-1-one
• CAS NO: 435273-55-5
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.072
• Mol File: 435273-55-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 356.577°C at 760 mmHg
• Flash Point: 169.452°C
• Appearance: /
• Density: 1.589
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: 2-8°C
• PKA: -2.13±0.20(Predicted)
• CAS DataBase Reference: 4-BROMO-2-METHYLISOINDOLIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-METHYLISOINDOLIN-1-ONE(435273-55-5)
• EPA Substance Registry System: 4-BROMO-2-METHYLISOINDOLIN-1-ONE(435273-55-5)

Safety Data

• Hazardous Substances Data: 435273-55-5(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-methylisoindolin-1-one is a specialized chemical compound represented by the molecular formula C9H8BrNO. It belongs to a class of organic compounds known as isoindolones, which are aromatic heterocyclic compounds that contain an isoindole bearing a ketone group at the 1-position. It is characterized by the presence of a bromine atom and a methyl group in its structure. Due to its specific structure, 4-Bromo-2-methylisoindolin-1-one usually finds applications in pharmaceutical research and development or in the synthesis of complex organic molecules. Detailed information about its physical and chemical properties, toxicity, or exact usage should be obtained from specific product data or scientific literature.

InChI:InChI=1/C9H8BrNO/c1-11-5-7-6(9(11)12)3-2-4-8(7)10/h2-4H,5H2,1H3

Upstream product

• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 99548-54-6 methyl 3-bromo-2-methylbenzoate 
• 74-89-5 methylamine 
• 337536-14-8 methyl 3-bromo-2-(bromomethyl)benzoate 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 1257996-66-9 4-bromo-2-methyl-7-nitro-2,3-dihydro-isoindol-1-one 
• 1380302-86-2 sodium ethyl (4-{[4-({7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate 
• 1257996-05-6 diethyl (4-{[4-({7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate 
• 1042722-39-3 2-(2-methyl-1-oxoisoindolin-4-yl)benzaldehyde 

Relevant articles and documents

CARBOLINE DERIVATIVE SERVING AS BROMODOMAIN INHIBITOR

Disclosed in the present invention is a carboline derivative serving as an bromodomain inhibitor. The carboline derivative in the present invention can be used as an bromodomain inhibitor, and can provide a method and a pharmaceutical composition for controlling diseases intervened by a bromodomain protein.

PHENANTHRENE LACTAM DERIVATIVES HAVING ANTICANCER ACTIVITY AND METHOD FOR THE PREPARATION THEREOF

The present invention relates to a phenanthrene lactam derivative having anticanter activity, a method for the preparation thereof, and a pharmaceutical composition comprising same.

Isoindolinone kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.